Carbenoxolone (CBX) is a glycyrrhetinic acid derivative with a steroid structure similar to what found in the roots of licorice plants.Carbenoxolone sodium is used to treat peptic, esophageal and oral ulcers and inflammation.Glycyrrhetinic Acid has also been used in topical creams that treating lip sores and oral ulcers.Licorice extract(beta glycyrrhetinic acid) is used in the field of cosmetics. Licorice extract(18 beta glycyrrhetinic acid) can nourish and heal the skin.
Pharmacological effects of Glycyrrhetinic Acid
1. Adrenal cortex hormone-like effects
(1) Mineralocorticoid-like effects
(2) Glucocorticoid-like effects
2. Anti-inflammatory and anti-immune effects
3. Antitussive and expectorant effect
4. Anti-tumor effect
5. Anti-diuretic effect
6. The scavenging effect on oxygen free radicals
| Specification | Standard |
| Appearance | White or almost white crystalline powder |
| Solubility | Practically insoluble in water, soluble in ethanol, sparingly soluble in methylene chloride, it shows polymophism |
| IR or TLC and coloured reaction | Positive |
| Appearance of solution | The solution is clear and not more than intensely coloured than reference solution Y6 |
| Specific optional rotation | +145°~ +154° |
| Any impurity | ≤0.7% |
| Total impurity | ≤2.0% |
| Loss on drying | ≤0.50% |
| Heavy metals | ≤10ppm |
| Sulphated Ash | ≤2.0% |
| Assay (by potentiometry, on dried substance) | 98.0-101.0% |