The best inhibitory effect on tyrosinase activity is deoxyarbutin [p-(tetrahydro-2H-pyran-2-oxy)phenol], which is 10 times more effective against melanin than hydroquinone. Acid 150 times, β-arbutin 350 times, α-arbutin 38.5 times. However, deoxyarbutin also has a major disadvantage, that is, it is unstable to light and heat in an aqueous solution, so there are still relatively few products using it on the market.