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Nonapeptide-1

Product Description

Nonapeptide-1 (also known as Melanostatine-5) is a proprietary peptide originally developed for its antibacterial activity.However, animal studies have shown that melitane can inhibit the synthesis of melanin,which makes it important in the treatment of certain skins. condition.Animal models show that melitane gel can reduce the synthesis of melanin and reduce skin pigmentation in a large extent.Nonapeptide 1 skincare products uased as whitening agent can play a role in the early stage of skin darkening mechanism.Nonapeptide-1 can prevent further activation of tyrosinase, thereby preventing the synthesis of melanin,so as to better control skin tone and brown spots.Melitane for grey hair treatment in cosmetics application.

Technical Date

FAQ

★What is Nonapeptide-1 and how does it work?

Nonapeptide-1 is a synthetic peptide of nine amino acids. It acts as an α-MSH antagonist, binding to MC1 receptors on melanocytes to block melanin production signals before they start.

★How is it different from other whitening ingredients like Vitamin C or Kojic Acid?

Vitamin C and Kojic Acid act downstream on tyrosinase. Nonapeptide-1 works upstream by blocking the hormonal signal (α-MSH) that activates tyrosinase. This prevents pigmentation at the source without irritation.

★Is this peptide listed in China's cosmetic ingredient catalog?

Yes. Nonapeptide-1 is officially listed in China's IECIC (2021 Edition) under sequence number 03642 as a permitted cosmetic ingredient with skin conditioning and hair conditioning functions.

★What is the approved safe usage concentration in China?

China NMPA data shows maximum historical usage: 2% for leave-on products (full body) and 2% for eye area (leave-on) . These concentrations are considered safe for cosmetic use.

★What is the recommended dosage for formulations?

Recommended usage is 5 to 25 ppm (0.0005% – 0.0025%) of active peptide powder. For best results, add during the cooling phase below 40°C at pH 5.0-7.0.

★What is the mechanism behind its skin brightening effect?

It competitively binds to MC1 receptors on melanocytes, preventing α-MSH from activating the melanin synthesis cascade. This downregulates tyrosinase, TRP-1, and MITF gene expression.

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Why Choose Us

Innovative Bio-active Enhancement Technology

Beyond simple extraction, ZHENYIBIO masters Enzymatic Hydrolysis and Liposomal Encapsulation to optimize the bio-availability of plant actives. Our in-house R&D team, led by industry PhDs, ensures that every batch of Glutathione or Centella Asiatica Extract meets the highest molecular stability standards.

Controlled Source & Farm-to-Lab Traceability

We operate our own botanical planting bases, ensuring 100% control over raw material quality from the seed. This vertical integration guarantees a stable, year-round supply and full traceability, helping you meet the strict transparency demands of modern "Clean Beauty" consumers.

Global Standards & GMP-Certified Excellence

Quality is our identity. ZHENYIBIO operates under strict GMP and ISO 9001 standards. All products are backed by comprehensive documentation, including COA, MSDS, and HPLC test reports, ensuring seamless compliance for EU (CPNP) and US (MoCRA) market entries.

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We don't just sell ingredients; we provide solutions. Our technical team offers formulation guidance to solve compatibility issues, while our global logistics network ensures fast, secure delivery to 50+ countries. Your success is our primary KPI.

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FAQs

How does ZHENYIBIO ensure the oxidative stability of whitening actives in water-based formulations?

We have developed a proprietary Anti-oxidation Stabilization System specifically designed for oxidation-prone active ingredients (such as glutathione). By controlling residual heavy metals in the raw materials—the primary catalysts for oxidation—and recommending a complementary chelating agent regimen, we ensure that the ingredients remain free from browning over extended periods within a pH range of 5.0 to 7.0.

Are your botanical brightening extracts compatible with high-concentration electrolytes?

Our plant extracts undergo a multi-stage refining process to remove the majority of inorganic salts and impurities; as a result, they exhibit excellent compatibility within serum formulations containing thickeners or high concentrations of electrolytes, without giving rise to flocculation or phase separation.

What technologies does ZHENYIBIO use to improve the skin penetration of plant-derived actives?

For large-molecule plant-derived active ingredients, we employ Liposomal Encapsulation and Micronization technologies. These techniques significantly reduce particle size, enabling active ingredients—such as Alpha-Arbutin—to more easily penetrate the stratum corneum and reach the areas where melanocytes are concentrated.

Can you provide In-vitro or In-vivo efficacy data for your whitening product line?

Yes. In addition to providing standard TDS documents, we can—upon request—supply data from Tyrosinase Inhibition Tests as well as Human Patch Test reports to support clinical claims regarding the "whitening efficacy" of your finished products.

Do ZHENYIBIO whitening ingredients meet the regulatory requirements of EU and North America?

Fully Compliant. Our products strictly adhere to both EU (Regulation EC No 1223/2009) and US MoCRA standards. A complete Certificate of Analysis (COA) is provided for every batch of raw materials, ensuring that levels of heavy metals, microbial contaminants, and residual solvents remain well below international regulatory limits.

Are your products "Clean Beauty" compliant (Vegan, Non-GMO, Cruelty-Free)?

Yes. As experts in Natural Plant Actives, we pledge that all our ingredients are derived from sustainable plant sources, contain no animal-derived components, involve no animal testing, and are accompanied by comprehensive traceability statements—empowering your brand to enter the clean beauty sector.

How do you guarantee a stable supply of botanical raw materials regardless of seasonal changes?

ZHENYIBIO maintains its own proprietary botanical cultivation bases. Through controlled environments and standardized harvesting processes, we are able to not only guarantee year-round stock availability but also ensure a high degree of consistency in the content of active ingredients—such as Glabridin—across different production batches.

Can ZHENYIBIO develop customized ingredient concentrations for specific brand requirements?

We can provide customized Standardized Extracts tailored to our clients' specific needs. Whether you require high-purity active monomers or blended ingredients in specific ratios, our R&D laboratory is equipped to make precise adjustments to meet your exact formulation requirements.