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Hydroxyethylpiperazine Ethane Sulfonic Acid

Product Description

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID has a certain effect of softening cutin and assisting in whitening; in cosmetics, it is a hydrogen ion buffer, which can control a constant pH range for a long time. Hydroxyethylpiperazine ethane sulfonic acid is a very effective biological buffer, which can reform the stratum corneum and promote the metabolism of skin keratinocytes. It is an important mild exfoliating ingredient.

The efficacy of hydroxyethylpiperazine ethane sulfonic acid: Weak acid system, Promote the absorption of active ingredients, Synergistic sun protection, Whitening effect, Adjust the PH value of the product.

FAQ

★Is Hydroxyethylpiperazine Ethane Sulfonic Acid listed in China's cosmetic ingredient catalog?

Yes. HEPES is officially listed in China's IECIC (2021 Edition) under sequence number 05290 . It is not a prohibited substance under China's Safety and Technical Standards for Cosmetics.

★What are the approved safe usage concentrations?

China historical maximum: 10% for leave-on products . The highest use concentration recorded is 8.26% for full-body leave-on and 5% for eye area. For rinse-off products, up to 8.26% is safe.

★What is the recommended dosage for cosmetic formulations?

Recommended usage is 0.1% to 8.26% in finished formulations . For maximum efficacy in exfoliating serums and penetration-enhancing formulas, use at higher concentrations within the safe limit.

★What is te solubility and incorporation method?

HEPES is water-soluble . Dissolve in water before adding to the formulation . For best results, incorporate during the water phase at controlled temperatures.

★What are the potential risk substances in HEPES?

Potential risk substances include dioxane and diethylene glycol that may be introduced during manufacturing. Request testing documentation for these impurities from your supplier.

★Does HEPES comply with EU, US FDA, and ASEAN cosmetic regulations?

Fully aligns with EU EC 1223/2009 (no animal testing required, PIF documentation supported), US FDA cosmetic ingredient safety standards, and ASEAN raw material registration rules. We provide full regulatory documents (COA, MSDS, safety assessment) for global customs clearance and formula filing.

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FAQs

How does ZHENYIBIO ensure the oxidative stability of whitening actives in water-based formulations?

We have developed a proprietary Anti-oxidation Stabilization System specifically designed for oxidation-prone active ingredients (such as glutathione). By controlling residual heavy metals in the raw materials—the primary catalysts for oxidation—and recommending a complementary chelating agent regimen, we ensure that the ingredients remain free from browning over extended periods within a pH range of 5.0 to 7.0.

Are your botanical brightening extracts compatible with high-concentration electrolytes?

Our plant extracts undergo a multi-stage refining process to remove the majority of inorganic salts and impurities; as a result, they exhibit excellent compatibility within serum formulations containing thickeners or high concentrations of electrolytes, without giving rise to flocculation or phase separation.

What technologies does ZHENYIBIO use to improve the skin penetration of plant-derived actives?

For large-molecule plant-derived active ingredients, we employ Liposomal Encapsulation and Micronization technologies. These techniques significantly reduce particle size, enabling active ingredients—such as Alpha-Arbutin—to more easily penetrate the stratum corneum and reach the areas where melanocytes are concentrated.

Can you provide In-vitro or In-vivo efficacy data for your whitening product line?

Yes. In addition to providing standard TDS documents, we can—upon request—supply data from Tyrosinase Inhibition Tests as well as Human Patch Test reports to support clinical claims regarding the "whitening efficacy" of your finished products.

Do ZHENYIBIO whitening ingredients meet the regulatory requirements of EU and North America?

Fully Compliant. Our products strictly adhere to both EU (Regulation EC No 1223/2009) and US MoCRA standards. A complete Certificate of Analysis (COA) is provided for every batch of raw materials, ensuring that levels of heavy metals, microbial contaminants, and residual solvents remain well below international regulatory limits.

Are your products "Clean Beauty" compliant (Vegan, Non-GMO, Cruelty-Free)?

Yes. As experts in Natural Plant Actives, we pledge that all our ingredients are derived from sustainable plant sources, contain no animal-derived components, involve no animal testing, and are accompanied by comprehensive traceability statements—empowering your brand to enter the clean beauty sector.

How do you guarantee a stable supply of botanical raw materials regardless of seasonal changes?

ZHENYIBIO maintains its own proprietary botanical cultivation bases. Through controlled environments and standardized harvesting processes, we are able to not only guarantee year-round stock availability but also ensure a high degree of consistency in the content of active ingredients—such as Glabridin—across different production batches.

Can ZHENYIBIO develop customized ingredient concentrations for specific brand requirements?

We can provide customized Standardized Extracts tailored to our clients' specific needs. Whether you require high-purity active monomers or blended ingredients in specific ratios, our R&D laboratory is equipped to make precise adjustments to meet your exact formulation requirements.