Home / Products / Cosmetic Peptide / Palmitoyl Tripeptide-5

PRODUCTS CATEGORY

Whitening & Lightening Moisturizing Anti-Aging Anti-Oxidant Anti-Inflammatory Tanning Cosmetic Peptide Liposomal Cosmetic Ingredients Natural Ingredients

Share to:

Palmitoyl Tripeptide-5

Product Description

Palmitoyl Tripeptide-5 belongs to the signaling peptide class and is the most widely used cosmetic small molecule peptide. Its cosmetic efficacy is comparable to that of injecting collagen.

Research has shown that such peptides promote the synthesis of collagen (types I, II, and IV) and the generation of extracellular matrix proteins by increasing stromal cell activity, strengthening connective tissue, promoting cell activity, and making the skin appear younger and more elastic. Many famous foreign cosmetics brands (such as Est é e Lauder, Chanel, Avon, etc.) use palmitoyl tripeptide-5 as a nutritional anti wrinkle ingredient because it has the ability to promote the synthesis of collagen and elastin in the dermis, making it an ideal raw material for accelerating collagen production and repairing wrinkles. Adding it to cosmetics can help the skin replenish collagen, enhance facial elasticity, and significantly reduce facial wrinkles. At the same time, it also has the characteristics of enhancing cell activity, increasing skin moisture content, enhancing skin gloss, and improving skin tone. In addition, it also has the effect of moisturizing the lips.

Technical Date

FAQ

★What is Palmitoyl Tripeptide-5 and what makes it unique?

Palmitoyl Tripeptide-5 (CAS: 623172-56-5, Pal-KVK) is a lipopeptide that mimics TGF-β activity. Unlike general collagen stimulators, it activates the TGF-β/Smad pathway to specifically regenerate Type I and III collagen, addressing the root cause of skin elasticity loss.

★What is the collagen regeneration mechanism?

It binds to TGF-β receptors on dermal fibroblasts, activating Smad signaling to upregulate Type I (80% of dermal collagen) and Type III (youthful elasticity) collagen genes. The palmitoyl modification achieves 78% dermal penetration, 3x higher than non-modified peptides.

★What is the recommended dosage?

Standard usage rate is 1% to 5% in finished formulations. For anti-wrinkle serums and firming creams, 2-3% is typical. For daily moisturizers and eye treatments, 1-2% provides effective results. Purity is ≥99% as lyophilized powder.

★What types of products can include Palmitoyl Tripeptide-5?

Palmitoyl Tripeptide-5 can be incorporated into a wide range of cosmetic formulations, including anti-aging serums, wrinkle repair creams, firming lotions, and eye care products. Its versatility makes it suitable for both lightweight and rich formulations targeting mature or aging skin.

★Is Palmitoyl Tripeptide-5 more effective than topical collagen?

Palmitoyl Tripeptide-5 is generally considered more effective than topical collagen because it stimulates the skin to produce its own collagen rather than simply providing surface hydration. This leads to deeper and longer-lasting improvements in skin structure and firmness.

★What is the safety profile?

Palmitoyl Tripeptide-5 has an excellent safety profile as a synthetic biomimetic peptide. It is not on restricted substance lists and shows anti-inflammatory properties. No significant irritation or allergic reactions have been reported at recommended usage levels.

Tel：+8615309206328

WhatsApp： +8613572414292

E-mail： alexxue@zhenyibio.com

Phone：+86-029-81294858

Related Products

丨丨丨丨丨丨

丨丨丨丨丨丨丨

Why Choose Us

Innovative Bio-active Enhancement Technology

Beyond simple extraction, ZHENYIBIO masters Enzymatic Hydrolysis and Liposomal Encapsulation to optimize the bio-availability of plant actives. Our in-house R&D team, led by industry PhDs, ensures that every batch of Glutathione or Centella Asiatica Extract meets the highest molecular stability standards.

Controlled Source & Farm-to-Lab Traceability

We operate our own botanical planting bases, ensuring 100% control over raw material quality from the seed. This vertical integration guarantees a stable, year-round supply and full traceability, helping you meet the strict transparency demands of modern "Clean Beauty" consumers.

Global Standards & GMP-Certified Excellence

Quality is our identity. ZHENYIBIO operates under strict GMP and ISO 9001 standards. All products are backed by comprehensive documentation, including COA, MSDS, and HPLC test reports, ensuring seamless compliance for EU (CPNP) and US (MoCRA) market entries.

Consultative Technical & Logistic Support

We don't just sell ingredients; we provide solutions. Our technical team offers formulation guidance to solve compatibility issues, while our global logistics network ensures fast, secure delivery to 50+ countries. Your success is our primary KPI.

Company Certificates

FAQs

How does ZHENYIBIO ensure the oxidative stability of whitening actives in water-based formulations?

We have developed a proprietary Anti-oxidation Stabilization System specifically designed for oxidation-prone active ingredients (such as glutathione). By controlling residual heavy metals in the raw materials—the primary catalysts for oxidation—and recommending a complementary chelating agent regimen, we ensure that the ingredients remain free from browning over extended periods within a pH range of 5.0 to 7.0.

Are your botanical brightening extracts compatible with high-concentration electrolytes?

Our plant extracts undergo a multi-stage refining process to remove the majority of inorganic salts and impurities; as a result, they exhibit excellent compatibility within serum formulations containing thickeners or high concentrations of electrolytes, without giving rise to flocculation or phase separation.

What technologies does ZHENYIBIO use to improve the skin penetration of plant-derived actives?

For large-molecule plant-derived active ingredients, we employ Liposomal Encapsulation and Micronization technologies. These techniques significantly reduce particle size, enabling active ingredients—such as Alpha-Arbutin—to more easily penetrate the stratum corneum and reach the areas where melanocytes are concentrated.

Can you provide In-vitro or In-vivo efficacy data for your whitening product line?

Yes. In addition to providing standard TDS documents, we can—upon request—supply data from Tyrosinase Inhibition Tests as well as Human Patch Test reports to support clinical claims regarding the "whitening efficacy" of your finished products.

Do ZHENYIBIO whitening ingredients meet the regulatory requirements of EU and North America?

Fully Compliant. Our products strictly adhere to both EU (Regulation EC No 1223/2009) and US MoCRA standards. A complete Certificate of Analysis (COA) is provided for every batch of raw materials, ensuring that levels of heavy metals, microbial contaminants, and residual solvents remain well below international regulatory limits.

Are your products "Clean Beauty" compliant (Vegan, Non-GMO, Cruelty-Free)?

Yes. As experts in Natural Plant Actives, we pledge that all our ingredients are derived from sustainable plant sources, contain no animal-derived components, involve no animal testing, and are accompanied by comprehensive traceability statements—empowering your brand to enter the clean beauty sector.

How do you guarantee a stable supply of botanical raw materials regardless of seasonal changes?

ZHENYIBIO maintains its own proprietary botanical cultivation bases. Through controlled environments and standardized harvesting processes, we are able to not only guarantee year-round stock availability but also ensure a high degree of consistency in the content of active ingredients—such as Glabridin—across different production batches.

Can ZHENYIBIO develop customized ingredient concentrations for specific brand requirements?

We can provide customized Standardized Extracts tailored to our clients' specific needs. Whether you require high-purity active monomers or blended ingredients in specific ratios, our R&D laboratory is equipped to make precise adjustments to meet your exact formulation requirements.