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Alpha Ketoglutarate

Product Description

Alpha-Ketoglutarate (AKG) is a vital biological molecule that plays a central role in the Krebs cycle, acting as a key intermediate in cellular energy production and amino acid metabolism. At ZHENYIBIO, our specialized factory utilizes high-purity synthesis and stabilization technology to provide premium Alpha-Ketoglutarate powder, including its most popular forms: Calcium Alpha-Ketoglutarate (Ca-AKG) and Arginine Alpha-Ketoglutarate (AAKG). As professional manufacturers, we focus on providing a stable, high-bioavailability ingredient that supports healthy aging and athletic performance. This versatile compound is highly sought after by global manufacturers of longevity supplements and sports nutrition.

Benefits of Alpha Ketoglutarate

Longevity & Anti-Aging: Helps reduce biological age by supporting DNA repair and systemic metabolic health.

Muscle Recovery & Performance: Enhances nitric oxide production and protein synthesis, making it a staple for sports nutrition suppliers.

Metabolic Support: Plays a critical role in the synthesis of glutamine and glutamate, supporting intestinal and immune health.

Kidney Health: Assists in nitrogen balance and detoxification, frequently utilized in specialized clinical nutrition.

Applications of Alpha Ketoglutarate

Longevity Supplements: The primary ingredient in NMN/AKG anti-aging formulas for global manufacturers.

Sports Nutrition: Pre-workout and recovery powders focusing on endurance and muscle growth.

Functional Food & Beverages: Health-boosting additives for metabolic wellness.

Technical Date

FAQ

★What is Alpha-Ketoglutarate and how does it work?

Alpha-Ketoglutarate is a key metabolic intermediate in the Krebs cycle, essential for energy (ATP) production. It also plays a vital role in amino acid synthesis, nitrogen transport, and cellular signaling, acting as a "master regulator" of metabolism.

★What are the main benefits of Alpha-Ketoglutarate for longevity?

Recent studies suggest that AKG can extend lifespan by inhibiting mTOR pathways and reducing systemic inflammation. It is widely used in anti-aging supplements to support cellular repair and delay age-related physiological decline.

What is the difference between AKG and Calcium Alpha-Ketoglutarate (Ca-AKG)?AKG is the pure acid form, while Ca-AKG is its calcium salt. Ca-AKG is more stable, less acidic, and has better bioavailability in the digestive tract, making it the preferred form for dietary supplements and capsules.

★Can Alpha-Ketoglutarate improve athletic performance?

It is a popular ingredient in sports nutrition. By improving ammonia clearance and supporting protein synthesis, it helps reduce muscle fatigue, enhances endurance, and accelerates post-workout recovery.

★Is Alpha-Ketoglutarate used in skincare and cosmetics?

It stimulates collagen synthesis and promotes skin cell regeneration. Its antioxidant properties help protect skin from oxidative stress, making it an effective ingredient for anti-wrinkle and skin-firming products.

★Is your Alpha-Ketoglutarate powder Vegan and Non-GMO?

As a leading supplier, our AKG is produced through high-quality fermentation, ensuring it is 100% vegan-friendly, non-GMO, and free from animal-derived ingredients.

★Can Alpha-Ketoglutarate be used in animal feed?

AKG is used as a functional feed additive to improve growth rates, gut health, and stress resistance in livestock and aquaculture, especially during early developmental stages.

Tel：+8615309206328

WhatsApp： +8615309206328

E-mail： alexxue@zhenyibio.com

Phone：+86-029-81294858

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Why Choose Us

Innovative Bio-active Enhancement Technology

Beyond simple extraction, ZHENYIBIO masters Enzymatic Hydrolysis and Liposomal Encapsulation to optimize the bio-availability of plant actives. Our in-house R&D team, led by industry PhDs, ensures that every batch of Glutathione or Centella Asiatica Extract meets the highest molecular stability standards.

Controlled Source & Farm-to-Lab Traceability

We operate our own botanical planting bases, ensuring 100% control over raw material quality from the seed. This vertical integration guarantees a stable, year-round supply and full traceability, helping you meet the strict transparency demands of modern "Clean Beauty" consumers.

Global Standards & GMP-Certified Excellence

Quality is our identity. ZHENYIBIO operates under strict GMP and ISO 9001 standards. All products are backed by comprehensive documentation, including COA, MSDS, and HPLC test reports, ensuring seamless compliance for EU (CPNP) and US (MoCRA) market entries.

Consultative Technical & Logistic Support

We don't just sell ingredients; we provide solutions. Our technical team offers formulation guidance to solve compatibility issues, while our global logistics network ensures fast, secure delivery to 50+ countries. Your success is our primary KPI.

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FAQs

How does ZHENYIBIO ensure the oxidative stability of whitening actives in water-based formulations?

We have developed a proprietary Anti-oxidation Stabilization System specifically designed for oxidation-prone active ingredients (such as glutathione). By controlling residual heavy metals in the raw materials—the primary catalysts for oxidation—and recommending a complementary chelating agent regimen, we ensure that the ingredients remain free from browning over extended periods within a pH range of 5.0 to 7.0.

Are your botanical brightening extracts compatible with high-concentration electrolytes?

Our plant extracts undergo a multi-stage refining process to remove the majority of inorganic salts and impurities; as a result, they exhibit excellent compatibility within serum formulations containing thickeners or high concentrations of electrolytes, without giving rise to flocculation or phase separation.

What technologies does ZHENYIBIO use to improve the skin penetration of plant-derived actives?

For large-molecule plant-derived active ingredients, we employ Liposomal Encapsulation and Micronization technologies. These techniques significantly reduce particle size, enabling active ingredients—such as Alpha-Arbutin—to more easily penetrate the stratum corneum and reach the areas where melanocytes are concentrated.

Can you provide In-vitro or In-vivo efficacy data for your whitening product line?

Yes. In addition to providing standard TDS documents, we can—upon request—supply data from Tyrosinase Inhibition Tests as well as Human Patch Test reports to support clinical claims regarding the "whitening efficacy" of your finished products.

Do ZHENYIBIO whitening ingredients meet the regulatory requirements of EU and North America?

Fully Compliant. Our products strictly adhere to both EU (Regulation EC No 1223/2009) and US MoCRA standards. A complete Certificate of Analysis (COA) is provided for every batch of raw materials, ensuring that levels of heavy metals, microbial contaminants, and residual solvents remain well below international regulatory limits.

Are your products "Clean Beauty" compliant (Vegan, Non-GMO, Cruelty-Free)?

Yes. As experts in Natural Plant Actives, we pledge that all our ingredients are derived from sustainable plant sources, contain no animal-derived components, involve no animal testing, and are accompanied by comprehensive traceability statements—empowering your brand to enter the clean beauty sector.

How do you guarantee a stable supply of botanical raw materials regardless of seasonal changes?

ZHENYIBIO maintains its own proprietary botanical cultivation bases. Through controlled environments and standardized harvesting processes, we are able to not only guarantee year-round stock availability but also ensure a high degree of consistency in the content of active ingredients—such as Glabridin—across different production batches.

Can ZHENYIBIO develop customized ingredient concentrations for specific brand requirements?

We can provide customized Standardized Extracts tailored to our clients' specific needs. Whether you require high-purity active monomers or blended ingredients in specific ratios, our R&D laboratory is equipped to make precise adjustments to meet your exact formulation requirements.