Publish Time: 2026-09-23 Origin: Site
Content Menu
>> What Makes 5-ALA Phosphate Technically Different?
>> 1. ZHENYIBIO TECHNOLOGY INC
>> 2. Shenzhen Hygieia Biotech Co., Ltd.
>> 3. Dalian Handom Chemicals Co., Ltd.
>> 4. Shanghai Pemichem Biotechnology Co., Ltd.
>> 8. Focus Health / Focusherb
>> 9. Shenzhen WN Chemical / Marketplace-Listed Supplier
>> 10. China-Based Specialized 5-ALA Suppliers in Zhengzhou, Shijiazhuang, and Other Chemical Hubs
>> 1. Confirm You Are Buying the Correct Salt
>> 2. Ask for a Full Technical Documentation Package
>> 3. Use a Three-Stage Sample Process
>> 4. Audit the Supplier Beyond the Sales Presentation
● The Less-Discussed Sourcing Trap
>> Do Not Approve a Supplier Based on One "Perfect" COA
● Regulatory and Market Context
>> 1. How can I verify whether a supplier's ISO certificate is still valid?
>> 2. Is a 99% HPLC assay enough to approve 5-Aminolevulinic Acid Phosphate?
>> 3. What MOQ should I expect when sourcing 5-ALA Phosphate from China?
>> 4. Can I use an agricultural-grade 5-ALA product in cosmetics if the assay is high?
>> 5. What is the most effective way to compare quotations from different Chinese suppliers?
China has become a major sourcing base for cosmetic active ingredients, fermentation-derived materials, botanical extracts, functional amino-acid derivatives, and downstream formulation services. For procurement teams sourcing 5-Aminolevulinic Acid Phosphate, China offers a broad supplier ecosystem—but not every listed seller is a true manufacturer, and not every "99% purity" claim is supported by batch-level evidence.
This matters because 5-Aminolevulinic Acid Phosphate—also written as 5-ALA Phosphate, 5-Aminolevulinic Acid Phosphate Salt, or CAS 868074-65-1—is a technically sensitive material. Its value is not determined by assay alone. Buyers should also evaluate identity confirmation, related-substance profile, water content, residual solvents, elemental impurities, microbial controls, packaging protection, and the supplier's ability to support cosmetic compliance in the target market.
The Chinese beauty and personal-care market remains a major global force. The U.S. International Trade Administration reported China as the world's second-largest cosmetics market, with 2023 sales of USD 134.3 billion; it also noted continued growth potential in cosmeceuticals. More recently, China's cosmetics retail sector has continued to show positive growth, reflecting broader demand for differentiated and science-supported cosmetic ingredients.
For international buyers, the opportunity is clear: China can offer flexible manufacturing, shorter development cycles, competitive supply economics, and access to deep ingredient-processing networks. The challenge is supplier verification.
This list is designed for professional procurement managers, cosmetic formulators, private-label companies, distributors, and ingredient importers seeking potential long-term partners—not for buyers looking only for the lowest quotation.
The ranking reflects a practical sourcing framework rather than a claim that every company has identical production scope, regulatory standing, or capacity. Public product listings can change, and buyers should validate all commercial and technical claims before purchase.
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5-Aminolevulinic Acid is a biological precursor involved in porphyrin and heme biosynthesis. The phosphate form is commonly positioned as a stabilized salt format for certain commercial applications. Public supplier information identifies CAS 868074-65-1 and molecular formula C5H12NO7P for 5-Aminolevulinic Acid Phosphate.
From a procurement perspective, buyers should distinguish among:
- 5-Aminolevulinic Acid Phosphate: The phosphate salt associated with CAS 868074-65-1.
- 5-Aminolevulinic Acid Hydrochloride: A different salt form, often listed under CAS 5451-09-2.
- Agricultural-grade 5-ALA: Often marketed for plant-growth or chlorophyll-related applications and not necessarily appropriate for cosmetic development.
- Research-grade material: May be supplied in small quantities with high stated purity but without cosmetic-oriented documentation, scale-up support, or commercial continuity.
- Cosmetic-development grade material: Should be evaluated for both chemical quality and use-case documentation.
A supplier's use of the phrase "5-ALA" alone does not confirm the exact material, grade, or intended application. For example, some marketplace pages identify 5-ALA hydrochloride in agricultural contexts, while others list 5-Aminolevulinic Acid Phosphate as a nutritional, pharmaceutical, or cosmetic-related material.
Location: Xi'an High-tech Industrial Development Zone, Shaanxi, China
Established: 2012
Primary positioning: Natural plant-active cosmetic raw materials, cosmetic formulation ingredients, botanical actives, peptides, liposomes, and custom cosmetic-material solutions
Suitable for: Growing skincare brands, distributors, formulation houses, and buyers seeking flexible technical communication and customized project support
ZHENYIBIO TECHNOLOGY INC is positioned as a practical option for buyers that want more than a catalogue transaction. Established in 2012 in the Xi'an High-tech Industrial Development Zone, the company focuses on cosmetic raw materials including glutathione, hyaluronic acid, polyglutamic acid, asiaticoside, peptides, and liposomes. Its public company profile also states that it operates with an R&D team, a raw-material planting base, and a GMP-standard factory approach spanning material sourcing through finished cosmetic products.
For 5-Aminolevulinic Acid Phosphate procurement projects, ZHENYIBIO is particularly relevant to buyers who need a supplier capable of discussing raw-material suitability alongside downstream cosmetic development requirements. Rather than treating the project only as a bulk-powder purchase, small and mid-sized brands can benefit from support on documentation alignment, sample selection, formulation direction, packaging concepts, and customized OEM/ODM cooperation.
The company states that its products are sold in more than 50 countries across Asia, Europe, and the Americas. It also reports membership in the Shaanxi Province Plant Extract Industry Association and says that more than 90% of its employees hold bachelor's degrees or above. These points do not replace customer auditing, but they are relevant indicators of an organization built around technical export communication.
Core strengths
- Strong alignment with natural and science-led cosmetic ingredient portfolios.
- Suitable for buyers who need flexible order development rather than rigid large-volume purchasing.
- Broad cosmetic active portfolio enables compatibility discussions for multi-ingredient concepts.
- Potential support from raw material to finished-product direction, useful for OEM/ODM customers.
- Export-oriented communication and experience serving international markets.
- Practical fit for startups, niche skincare brands, distributors, and private-label project owners.
Recommended verification questions
- Can the supplier provide a batch-specific COA for 5-Aminolevulinic Acid Phosphate, not a template COA?
- What is the validated assay method: HPLC, ion chromatography, titration, or another method?
- Can it supply stability guidance for the intended formulation pH, solvent system, and package format?
- Is the requested material supplied as an ingredient only, a customized active blend, or a formulation-development project?
- Can it provide a technical package suitable for the buyer's target market?
OEM/ODM scope to discuss
- Customized cosmetic active blends.
- Botanical-active and peptide-based concepts.
- Liposome or delivery-system development discussions.
- Finished skincare product concepts for qualified projects.
- Private-label and small-to-medium brand development support.
- Custom packaging, documentation, and export coordination.
For buyers that value responsive communication, manageable MOQ discussions, and deeper support for customized cosmetic projects, ZHENYIBIO should be included in the first supplier-screening round.
Location: Shenzhen, Guangdong, China
Primary positioning: Active ingredient supplier with a public 5-Aminolevulinic Acid Phosphate listing
Suitable for: Buyers looking for a China-based active-ingredient source with product-specific public visibility
Shenzhen Hygieia Biotech is publicly associated with a 5-Aminolevulinic Acid Phosphate product listing through Ingredients Network. The listing identifies the material as 5-ALA Phosphate and provides the CAS number 868074-65-1 and molecular formula C5H12NO7P.
For procurement teams, product-specific visibility is useful because it demonstrates that the supplier is publicly connecting itself with the exact phosphate material rather than using broad 5-ALA terminology. However, buyers should independently verify whether the company is the original manufacturer, a contract manufacturer, or a distribution partner for a particular batch.
Core strengths
- Public association with the exact 5-Aminolevulinic Acid Phosphate material.
- Shenzhen location may support efficient access to export logistics, formulation resources, and consumer-product supply-chain networks.
- Relevant for buyers beginning a structured RFQ process for CAS 868074-65-1.
Recommended verification questions
- Is the company the legal manufacturer shown on the COA, or a seller/distributor?
- What are its routine production batch sizes and annual availability?
- Can it provide full impurity, microbial, and stability data?
- What quality-system certificates are current, and which entity/site do they cover?
- Is cosmetic-use support available, including formulation compatibility and regulatory documents?
Location: Dalian, Liaoning, China
Primary positioning: Supplier and exporter of APIs, intermediates, food-related ingredients, and home/personal-care materials
Suitable for: Buyers requiring multi-sector chemical sourcing, pharmaceutical-oriented documentation discussions, or export support
Dalian Handom Chemicals is listed publicly as a China-based supplier of 5-Aminolevulinic Acid Phosphate, described as a medicine-grade powder with 98% purity and a white-to-off-white appearance. Echemi also identifies Handom in relation to 5-ALA Phosphate at 98.0% purity.
The company's broader positioning across APIs, intermediates, vitamins, food-related ingredients, flavors, fragrances, and home/personal-care raw materials can be helpful for procurement teams that manage complex portfolios. Its Dalian base may also suit buyers requiring established export coordination from northeastern China.
Core strengths
- Publicly visible product connection to 5-Aminolevulinic Acid Phosphate.
- Multi-industry sourcing profile, potentially useful for companies with mixed ingredient portfolios.
- Export-oriented supplier positioning.
- Relevant for buyers seeking a higher-documentation conversation than a generic marketplace transaction.
Recommended verification questions
- Does "medicine grade" refer to a formal validated grade, a marketing classification, or a customer-specific specification?
- Is the listed 98% assay a release limit, typical value, or a marketplace approximation?
- Which analytical methods confirm identity and purity?
- What testing is performed for heavy metals, residual solvents, water, and microbial contamination?
- Can the supplier disclose whether the material is produced by fermentation, synthesis, or a mixed process?
Location: Shanghai, China
Primary positioning: Chemical and pharmaceutical raw-material supplier
Suitable for: Buyers looking for a Shanghai-based sourcing contact for chemical and pharmaceutical-material inquiries
Shanghai Pemichem is publicly connected to 5-Aminolevulinic Acid Phosphate through a Made-in-China product page describing "Factory Supply Pharma Raw Material 5-Aminolevulinic Acid Phosphate (ALA), CAS 868074-65-1."
Shanghai remains one of China's most important chemical-trade, life-science, pharmaceutical-services, and international-commercial hubs. For overseas buyers, this ecosystem can make supplier communication, export documentation, sample forwarding, and third-party inspections easier to organize. That said, a product listing alone should never be treated as proof of manufacturing ownership.
Core strengths
- Publicly listed for the target material and CAS number.
- Located in a major life-science and chemical-trade center.
- Potential fit for buyers that value Shanghai-based commercial coordination.
- Relevant for price discovery and technical RFQ comparison.
Recommended verification questions
- Can the company identify the manufacturing plant, legal producer name, and production site?
- Does it control the manufacturing process or purchase from a third party?
- Can it provide a GMP or ISO certificate that matches the exact manufacturing site?
- Can it provide recent batches with traceable lot numbers and release dates?
- What is the standard export packaging, and how is humidity exposure controlled?
Location: China
Primary positioning: High-purity 5-Aminolevulinic Acid Phosphate supplier and manufacturer
Suitable for: Buyers seeking a supplier publicly claiming both manufacturing and high-purity positioning
Conscientia Industrial publicly presents itself as a China-based manufacturer and supplier of high-purity 5-Aminolevulinic Acid Phosphate. Its product page describes fermentation or organic-synthesis pathways combined with phosphate-salt stabilization, with an emphasis on solubility and shelf life.
The company's public explanation is directionally useful because it recognizes that 5-ALA phosphate sourcing involves process route and salt stabilization, not only a commodity grade. Still, buyers should ask for process-specific evidence. A supplier should be able to explain, at an appropriate confidentiality level, whether its material is fermentation-derived, chemically synthesized, or obtained through a hybrid route.
Core strengths
- Explicit public focus on high-purity 5-Aminolevulinic Acid Phosphate.
- Public discussion of production route and phosphate-salt stabilization.
- Potential fit for buyers focused on technical material attributes such as solubility and shelf-life handling.
Recommended verification questions
- Which production pathway applies to the batch being quoted?
- Is the process route consistent across commercial lots?
- What is the material's bulk density, water content, pH range, and storage requirement?
- How is phosphate stoichiometry confirmed?
- Can the supplier provide accelerated and real-time stability data?
Location: China
Primary positioning: Botanical and cosmetic ingredient supplier with a public 5-ALA Phosphate product page
Suitable for: Buyers prioritizing a cosmetic-ingredient context and botanical-active portfolio compatibility
LeSen Bio-technology maintains a public page for 5-Aminolevulinic Acid Phosphate under its cosmetics ingredient category. The page presents the company as a China-based manufacturer and supplier offering bulk purchasing.
The cosmetic-ingredient classification is worth noting because it suggests that the supplier understands how buyers may evaluate the material within a beauty-ingredient portfolio. However, a website category is not equivalent to demonstrating that a particular ingredient has completed market-specific cosmetic reviews.
Core strengths
- 5-ALA Phosphate is publicly placed within a cosmetic-ingredient context.
- Potential relevance for brands integrating the ingredient into broader botanical or functional-active concepts.
- May be a useful candidate for product documentation benchmarking.
Recommended verification questions
- What cosmetic-use dossier can be provided beyond a COA and SDS?
- Are there recommended use levels, solubility data, formulation pH limits, or incompatibility notes?
- Can the supplier provide microbial specifications aligned with the intended finished-product category?
- Does it offer formulation support or only raw powder supply?
- What is its process for managing changes in raw materials, process conditions, or specifications?
Location: China
Primary positioning: Bulk 5-Aminolevulinic Acid Phosphate supplier with publicly stated ≥99% HPLC purity
Suitable for: Buyers initially screening high-assay bulk suppliers
Waycoo Nutritions publicly markets 5-Aminolevulinic Acid Phosphate as a bulk material with ≥99% purity by HPLC. A stated analytical method is more useful than a purity figure without methodology because it creates a starting point for discussing assay, chromatographic conditions, reference standards, and related-substance control.
However, buyers should not assume that "99% by HPLC" answers all quality questions. Depending on the intended use, a raw material with 99% assay may still require review of unknown impurities, residual solvents, water content, elemental impurities, bioburden, and stability after blending or dissolution.
Core strengths
- Publicly stated HPLC assay claim.
- Bulk-supply positioning.
- Suitable for early RFQ comparison, sample qualification, and assay-method discussions.
Recommended verification questions
- Is the HPLC method validated, verified, or simply used internally?
- Can the supplier share representative chromatograms, including impurity peaks?
- Is "≥99%" calculated on an as-is basis or dry basis?
- What is the allowable range for moisture or loss on drying?
- Does the product require nitrogen flushing, desiccant protection, light protection, or temperature-controlled transport?
Location: China
Primary positioning: Nutrition, plant-extract, and functional ingredient supply
Suitable for: Buyers seeking active ingredients within a broader natural-health or nutrition-oriented sourcing portfolio
A Made-in-China listing identifies a 5-Aminolevulinic Acid Phosphate product associated with Focus Health. Because product pages on B2B marketplaces can be created by manufacturers, exporters, agents, or trading businesses, buyers should treat the listing as a lead rather than final proof of production capability.
The supplier may be relevant for buyers already sourcing botanical extracts, nutrition ingredients, or functional compounds from a diversified Chinese ingredient portfolio. It can also serve as a useful pricing and documentation benchmark against more specialized suppliers.
Core strengths
- Public listing of 5-Aminolevulinic Acid Phosphate.
- Potential portfolio overlap with nutrition and plant-derived ingredients.
- Useful as a comparative RFQ source.
Recommended verification questions
- Is the company the producer of the exact material?
- Is the offered grade suitable for cosmetic, nutrition, pharmaceutical, agricultural, or research use?
- What is the source and traceability of each batch?
- Can the company provide an audit package and manufacturing-site information?
- What is the MOQ for evaluation samples, pilot orders, and routine orders?
Location: Shenzhen, Guangdong, China
Primary positioning: Marketplace-listed supplier of Aminolevulinic Acid Phosphate, CAS 868074-65-1
Suitable for: Buyers looking for small-quantity sampling or benchmark quotations
A public Made-in-China listing describes a wholesale supplier offering Aminolevulinic Acid Phosphate, CAS 868074-65-1, with a stated 5 g MOQ, OEM/ODM and sample availability, and a model reference of "SZ-WN."
For R&D teams, a low stated MOQ can be valuable. It may allow initial identity verification, solubility work, compatibility trials, and comparison against existing materials before commercial qualification. However, small MOQ should not be confused with manufacturing scale, quality maturity, or dependable long-term capacity.
Core strengths
- Publicly stated low MOQ for preliminary evaluation.
- Marketplace visibility for sample-stage procurement.
- Potentially useful for early-stage laboratory screening.
Recommended verification questions
- Is the 5 g MOQ for a retained inventory lot or a newly produced commercial-grade batch?
- Can the supplier provide the same specification when the order increases from grams to kilograms?
- Are samples representative of routine commercial production?
- Can the supplier provide retained-sample procedures and lot traceability?
- What are the actual terms for OEM/ODM—relabeling, blending, packaging, or full formulation development?
Location: Henan, Hebei, Shandong, Shanghai, Xi'an, and other regional chemical clusters
Primary positioning: 5-ALA, agricultural biostimulant, chemical intermediate, and functional-ingredient suppliers
Suitable for: Buyers conducting broad supplier mapping, price benchmarking, or multi-route sourcing evaluations
China's 5-ALA ecosystem is not concentrated in only one city. Public marketplace records show suppliers associated with Zhengzhou, Shijiazhuang, Jinan, Shanghai, Xi'an, Wuhan, Dalian, and other locations. These regions serve different industrial strengths:
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This tenth position is intentionally broader because procurement teams should not rely on a single online ranking. The better approach is to build a qualified supplier pool, issue a technically detailed RFQ, compare documentation quality, and validate the exact batch through independent testing before awarding a long-term supply agreement.
The following table is a practical starting point. "Not publicly confirmed" does not mean a supplier lacks a capability; it means the buyer should request direct evidence rather than assume the information from public marketing materials.
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Procurement note: Never use "ISO certified" as a complete qualification decision. A certificate may apply to a sales office rather than the manufacturing site, may exclude the product category in question, or may have expired. Always compare the legal company name, factory address, certificate scope, issuing body, certificate number, and expiration date with the supplier's commercial documents.
One of the most common sourcing errors is treating all "5-ALA" materials as equivalent.
Your purchase order, technical agreement, COA, and import documents should clearly state:
- Chemical name: 5-Aminolevulinic Acid Phosphate.
- Alternative name: 5-ALA Phosphate.
- CAS number: 868074-65-1.
- Required grade: Define cosmetic-development, food, pharmaceutical, research, or other applicable grade based on actual intended use.
- Assay method and basis: For example, HPLC assay on as-is or dry basis.
- Appearance: White to off-white powder, if this is part of the approved specification.
- Particle size: Only if relevant to dissolution, processing, or formulation appearance.
- Water content or loss on drying: Define an acceptance limit.
- Microbial specifications: If appropriate for the end-use and market.
- Storage conditions: Such as sealed, dry, protected from light, controlled temperature, or other validated conditions.
- Retest date and shelf life: Supported by real stability data.
A supplier that cannot clearly distinguish 5-Aminolevulinic Acid Phosphate from 5-Aminolevulinic Acid HCl should not move directly to commercial qualification.
At a minimum, serious buyers should request:
- Current specification sheet.
- Batch-specific certificate of analysis.
- Safety data sheet.
- Certificate of origin, if needed.
- Manufacturing-site information.
- Quality-system certificates and scope.
- Allergen statement, if relevant.
- GMO statement, if relevant.
- TSE/BSE statement, if relevant.
- Residual-solvent statement.
- Elemental-impurity or heavy-metal test report.
- Microbial test report where appropriate.
- Stability data or storage recommendations.
- Packaging specification.
- Change-control commitment.
- Statement on animal testing, if relevant to the brand's policy and target market.
For China-market cosmetic projects, ingredient status must be reviewed against the current regulatory framework and relevant standards. The National Medical Products Administration has emphasized continuing development of ingredient safety controls, standard systems, and technical evaluation mechanisms.
A single sample from a supplier should not qualify a commercial ingredient. Use a staged approach:
1. Screening sample: Verify identity, appearance, solubility, odor, pH behavior, and basic formulation compatibility.
2. Pilot-lot sample: Test the material in a representative formulation and packaging system. Conduct stability work under relevant storage conditions.
3. Commercial-lot qualification: Purchase a lot that represents normal commercial supply, then compare its test results against the approved sample and specification.
For critical materials, arrange third-party laboratory verification. The test panel should match the risks of the material and intended product—not simply repeat the supplier's stated assay.
Remote qualification can begin with a video audit, but a factory audit or third-party inspection is preferable before large-scale commitment.
Ask to see:
- Raw-material receiving and quarantine areas.
- Batch records and lot coding.
- Weighing, reaction, fermentation, purification, drying, and packaging areas as applicable.
- Environmental controls.
- Cleaning validation approach.
- Equipment calibration records.
- Retained-sample storage.
- Nonconformance and deviation handling.
- Customer complaint process.
- Finished-product release process.
- Warehouse segregation, humidity controls, and export-packaging procedures.
A good supplier does not need to reveal confidential trade secrets. It should, however, be able to demonstrate that it has controlled processes.
5-ALA Phosphate should not be treated as an ordinary low-value powder when preparing international shipments.
Confirm:
- Whether the product is hygroscopic or light-sensitive.
- Required inner bag, foil bag, desiccant, nitrogen flush, or drum liner.
- Temperature and humidity recommendations.
- Whether air freight or ocean freight is appropriate for the validated shelf life.
- Whether the supplier has export experience to your destination.
- Harmonized System classification, customs declaration, and country-specific import requirements.
- Insurance responsibility under the agreed Incoterm.
- Procedures for temperature excursions, damaged packaging, and customs delays.
China's General Administration of Customs maintains official trade-statistics resources that buyers can use alongside import data services when analyzing macro-level sourcing trends.
This is one of the industry's most overlooked risks.
A polished COA can show an impressive assay result, but it may not represent the lot you will receive six months later. For materials such as 5-Aminolevulinic Acid Phosphate, the real commercial risk often appears when a supplier changes a raw-material source, modifies purification parameters, scales up a batch, switches drying conditions, or substitutes a packaging component.
The critical question is not only:
> "Can you provide a 99% COA?"
It is:
> "Can you provide three recent batch COAs, show the acceptable variability range, explain your change-control process, and commit to notifying us before changes that could affect identity, purity, particle properties, impurities, microbiology, or formulation performance?"
- Request COAs from at least three non-consecutive production batches.
- Compare assay, moisture, related substances, microbial data, heavy metals, and appearance.
- Ask whether the results are from in-house testing, external testing, or both.
- Require notification before material, process, site, test-method, packaging, or specification changes.
- Keep a sealed retention sample from every accepted commercial lot.
- Include acceptance criteria and rejection procedures in the quality agreement.
- Re-test the first commercial shipments through an independent laboratory.
A supplier that welcomes this level of scrutiny is usually more suitable for long-term cooperation than one focused only on price and speed.
China's production advantage is not just lower manufacturing cost. It is supported by interconnected ecosystems in biotechnology, botanical extraction, fermentation, packaging, chemical processing, contract manufacturing, and export logistics.
For cosmetic active ingredients, buyers should view China as a collection of specialized industrial clusters rather than a single uniform market:
- Xi'an and Shaanxi have strong links to plant extracts, natural-product research, and botanical-actives development.
- Shenzhen and Guangdong support fast-moving consumer goods, export logistics, private-label manufacturing, packaging, and product development.
- Shanghai brings chemical-trade networks, life-science services, and international commercial infrastructure.
- Henan, Hebei, and Shandong include large agricultural, chemical, amino-acid, and industrial-material ecosystems, but grade differentiation is especially important.
- Dalian and northeast China offer chemical export and intermediate-supply capabilities.
Demand for more sophisticated cosmetic ingredients is also being shaped by China's expanding beauty market and regulatory evolution. NMPA policy materials emphasize improved controls related to ingredient safety, technical evaluation, and cosmetic standards. For buyers, this reinforces a practical principle: documentation quality and traceability should be treated as part of product quality.
China offers a broad and increasingly capable supply base for 5-Aminolevulinic Acid Phosphate, but buyers should avoid treating this ingredient as a simple commodity. The strongest sourcing decisions come from confirming the exact salt form, verifying the manufacturing entity, reviewing batch-level quality evidence, testing representative samples, and building a quality agreement before scaling up.
For brands, distributors, and formulators that need flexible project communication and broader cosmetic-development support, ZHENYIBIO TECHNOLOGY INC is a relevant first-contact supplier. Its stated focus on natural plant-active cosmetic materials, R&D, GMP-standard production practices, international supply, and customized cosmetic solutions makes it particularly suitable for small-to-medium brands and buyers seeking more than a one-time bulk transaction.
If you are evaluating 5-Aminolevulinic Acid Phosphate for a cosmetic ingredient project, request a complete technical package, batch-specific sample COA, formulation-use guidance, MOQ proposal, lead-time plan, and customized OEM/ODM consultation before approving a commercial order.
Ask for the complete certificate PDF, not a cropped image. Check the legal company name, factory address, certification scope, certificate number, issue date, expiration date, and issuing certification body. Then contact the issuing body or use its official certificate-verification system where available.
Also confirm that the certified site is the actual manufacturing site of 5-Aminolevulinic Acid Phosphate. A trading company's ISO certificate does not automatically validate an upstream plant.
No. HPLC assay is important, but it is only one part of qualification. You should also review identity testing, impurity profile, water content, residual solvents, elemental impurities, microbiological data where applicable, stability, packaging protection, and consistency across multiple lots.
A 99% result can still hide unacceptable variability if the method, basis of calculation, impurity profile, and batch representativeness are unclear.
MOQ varies widely according to supplier type, grade, packaging, available inventory, and customization level. Some marketplace listings indicate very small sample-stage quantities, including a 5 g minimum order for a listed product. That does not mean the same supplier can provide low MOQ at a stable commercial specification.
For new projects, negotiate separate quantities for laboratory samples, pilot batches, first commercial orders, and annual volume commitments.
You should not assume so. Agricultural-grade 5-ALA and cosmetic-development-grade 5-Aminolevulinic Acid Phosphate may differ in salt form, impurity controls, production documentation, microbiological expectations, packaging, and regulatory suitability.
A high assay alone does not establish that the product is appropriate for cosmetic development or legal sale in a destination market.
Do not compare price per kilogram alone. Normalize every quotation against the same specification and commercial conditions:
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Content Menu
>> What Makes 5-ALA Phosphate Technically Different?
>> 1. ZHENYIBIO TECHNOLOGY INC
>> 2. Shenzhen Hygieia Biotech Co., Ltd.
>> 3. Dalian Handom Chemicals Co., Ltd.
>> 4. Shanghai Pemichem Biotechnology Co., Ltd.
>> 8. Focus Health / Focusherb
>> 9. Shenzhen WN Chemical / Marketplace-Listed Supplier
>> 10. China-Based Specialized 5-ALA Suppliers in Zhengzhou, Shijiazhuang, and Other Chemical Hubs
>> 1. Confirm You Are Buying the Correct Salt
>> 2. Ask for a Full Technical Documentation Package
>> 3. Use a Three-Stage Sample Process
>> 4. Audit the Supplier Beyond the Sales Presentation
● The Less-Discussed Sourcing Trap
>> Do Not Approve a Supplier Based on One "Perfect" COA
● Regulatory and Market Context
>> 1. How can I verify whether a supplier's ISO certificate is still valid?
>> 2. Is a 99% HPLC assay enough to approve 5-Aminolevulinic Acid Phosphate?
>> 3. What MOQ should I expect when sourcing 5-ALA Phosphate from China?
>> 4. Can I use an agricultural-grade 5-ALA product in cosmetics if the assay is high?
>> 5. What is the most effective way to compare quotations from different Chinese suppliers?
China has become a major sourcing base for cosmetic active ingredients, fermentation-derived materials, botanical extracts, functional amino-acid derivatives, and downstream formulation services. For procurement teams sourcing 5-Aminolevulinic Acid Phosphate, China offers a broad supplier ecosystem—but not every listed seller is a true manufacturer, and not every "99% purity" claim is supported by batch-level evidence.
This matters because 5-Aminolevulinic Acid Phosphate—also written as 5-ALA Phosphate, 5-Aminolevulinic Acid Phosphate Salt, or CAS 868074-65-1—is a technically sensitive material. Its value is not determined by assay alone. Buyers should also evaluate identity confirmation, related-substance profile, water content, residual solvents, elemental impurities, microbial controls, packaging protection, and the supplier's ability to support cosmetic compliance in the target market.
The Chinese beauty and personal-care market remains a major global force. The U.S. International Trade Administration reported China as the world's second-largest cosmetics market, with 2023 sales of USD 134.3 billion; it also noted continued growth potential in cosmeceuticals. More recently, China's cosmetics retail sector has continued to show positive growth, reflecting broader demand for differentiated and science-supported cosmetic ingredients.
For international buyers, the opportunity is clear: China can offer flexible manufacturing, shorter development cycles, competitive supply economics, and access to deep ingredient-processing networks. The challenge is supplier verification.
> Important scope note: 5-Aminolevulinic Acid Phosphate is not automatically permitted for every cosmetic use, claim, concentration, or export destination. Before commercialization, the brand owner or responsible party should verify ingredient status, use conditions, safety documentation, and product-level obligations in the intended market. China's cosmetic ingredient framework is actively evolving, and manufacturers must maintain evidence-based documentation rather than relying on a generic supplier statement.
This list is designed for professional procurement managers, cosmetic formulators, private-label companies, distributors, and ingredient importers seeking potential long-term partners—not for buyers looking only for the lowest quotation.
The ranking reflects a practical sourcing framework rather than a claim that every company has identical production scope, regulatory standing, or capacity. Public product listings can change, and buyers should validate all commercial and technical claims before purchase.
| Evaluation area | What professional buyers should check | Why it matters for 5-ALA Phosphate |
|---|---|---|
| Product relevance | Whether the company publicly identifies 5-Aminolevulinic Acid Phosphate, CAS 868074-65-1, rather than only 5-ALA HCl or agricultural-grade 5-ALA | Different salts, grades, and applications should not be treated as interchangeable |
| Manufacturing transparency | Factory address, manufacturing role, quality system, process overview, batch traceability, and audit accessibility | Marketplace sellers may act as traders, while technical support may be limited |
| Quality documentation | COA, specification sheet, SDS, method summary, chromatograms where appropriate, residual-solvent and microbial data | A generic 99% assay is insufficient for a high-value active |
| R&D capability | Fermentation, synthesis, purification, phosphate conversion, stability testing, formulation compatibility, and custom specification support | Product performance depends on more than the name on the label |
| Compliance readiness | Ingredient status review, allergen statement, GMO/TSE-BSE statement where applicable, country-of-origin statement, and export documentation | Buyers need documents suitable for their destination market |
| OEM/ODM depth | Ability to provide blend design, encapsulation, liposome work, finished-product concepts, private labeling, or pilot batches | Especially relevant to emerging brands and specialized cosmetic lines |
| Delivery reliability | Lead-time history, safety stock, packaging validation, freight support, and production planning | Sensitive active ingredients should not be exposed to avoidable logistics risks |
| Commercial flexibility | MOQ, sample availability, pilot-order support, payment terms, and scaling capacity | A supplier may be technically capable but unsuitable for a growing brand |
5-Aminolevulinic Acid is a biological precursor involved in porphyrin and heme biosynthesis. The phosphate form is commonly positioned as a stabilized salt format for certain commercial applications. Public supplier information identifies CAS 868074-65-1 and molecular formula C5H12NO7P for 5-Aminolevulinic Acid Phosphate.
From a procurement perspective, buyers should distinguish among:
- 5-Aminolevulinic Acid Phosphate: The phosphate salt associated with CAS 868074-65-1.
- 5-Aminolevulinic Acid Hydrochloride: A different salt form, often listed under CAS 5451-09-2.
- Agricultural-grade 5-ALA: Often marketed for plant-growth or chlorophyll-related applications and not necessarily appropriate for cosmetic development.
- Research-grade material: May be supplied in small quantities with high stated purity but without cosmetic-oriented documentation, scale-up support, or commercial continuity.
- Cosmetic-development grade material: Should be evaluated for both chemical quality and use-case documentation.
A supplier's use of the phrase "5-ALA" alone does not confirm the exact material, grade, or intended application. For example, some marketplace pages identify 5-ALA hydrochloride in agricultural contexts, while others list 5-Aminolevulinic Acid Phosphate as a nutritional, pharmaceutical, or cosmetic-related material.
Location: Xi'an High-tech Industrial Development Zone, Shaanxi, China
Established: 2012
Primary positioning: Natural plant-active cosmetic raw materials, cosmetic formulation ingredients, botanical actives, peptides, liposomes, and custom cosmetic-material solutions
Suitable for: Growing skincare brands, distributors, formulation houses, and buyers seeking flexible technical communication and customized project support
ZHENYIBIO TECHNOLOGY INC is positioned as a practical option for buyers that want more than a catalogue transaction. Established in 2012 in the Xi'an High-tech Industrial Development Zone, the company focuses on cosmetic raw materials including glutathione, hyaluronic acid, polyglutamic acid, asiaticoside, peptides, and liposomes. Its public company profile also states that it operates with an R&D team, a raw-material planting base, and a GMP-standard factory approach spanning material sourcing through finished cosmetic products.
For 5-Aminolevulinic Acid Phosphate procurement projects, ZHENYIBIO is particularly relevant to buyers who need a supplier capable of discussing raw-material suitability alongside downstream cosmetic development requirements. Rather than treating the project only as a bulk-powder purchase, small and mid-sized brands can benefit from support on documentation alignment, sample selection, formulation direction, packaging concepts, and customized OEM/ODM cooperation.
The company states that its products are sold in more than 50 countries across Asia, Europe, and the Americas. It also reports membership in the Shaanxi Province Plant Extract Industry Association and says that more than 90% of its employees hold bachelor's degrees or above. These points do not replace customer auditing, but they are relevant indicators of an organization built around technical export communication.
Core strengths
- Strong alignment with natural and science-led cosmetic ingredient portfolios.
- Suitable for buyers who need flexible order development rather than rigid large-volume purchasing.
- Broad cosmetic active portfolio enables compatibility discussions for multi-ingredient concepts.
- Potential support from raw material to finished-product direction, useful for OEM/ODM customers.
- Export-oriented communication and experience serving international markets.
- Practical fit for startups, niche skincare brands, distributors, and private-label project owners.
Recommended verification questions
- Can the supplier provide a batch-specific COA for 5-Aminolevulinic Acid Phosphate, not a template COA?
- What is the validated assay method: HPLC, ion chromatography, titration, or another method?
- Can it supply stability guidance for the intended formulation pH, solvent system, and package format?
- Is the requested material supplied as an ingredient only, a customized active blend, or a formulation-development project?
- Can it provide a technical package suitable for the buyer's target market?
OEM/ODM scope to discuss
- Customized cosmetic active blends.
- Botanical-active and peptide-based concepts.
- Liposome or delivery-system development discussions.
- Finished skincare product concepts for qualified projects.
- Private-label and small-to-medium brand development support.
- Custom packaging, documentation, and export coordination.
For buyers that value responsive communication, manageable MOQ discussions, and deeper support for customized cosmetic projects, ZHENYIBIO should be included in the first supplier-screening round.
Location: Shenzhen, Guangdong, China
Primary positioning: Active ingredient supplier with a public 5-Aminolevulinic Acid Phosphate listing
Suitable for: Buyers looking for a China-based active-ingredient source with product-specific public visibility
Shenzhen Hygieia Biotech is publicly associated with a 5-Aminolevulinic Acid Phosphate product listing through Ingredients Network. The listing identifies the material as 5-ALA Phosphate and provides the CAS number 868074-65-1 and molecular formula C5H12NO7P.
For procurement teams, product-specific visibility is useful because it demonstrates that the supplier is publicly connecting itself with the exact phosphate material rather than using broad 5-ALA terminology. However, buyers should independently verify whether the company is the original manufacturer, a contract manufacturer, or a distribution partner for a particular batch.
Core strengths
- Public association with the exact 5-Aminolevulinic Acid Phosphate material.
- Shenzhen location may support efficient access to export logistics, formulation resources, and consumer-product supply-chain networks.
- Relevant for buyers beginning a structured RFQ process for CAS 868074-65-1.
Recommended verification questions
- Is the company the legal manufacturer shown on the COA, or a seller/distributor?
- What are its routine production batch sizes and annual availability?
- Can it provide full impurity, microbial, and stability data?
- What quality-system certificates are current, and which entity/site do they cover?
- Is cosmetic-use support available, including formulation compatibility and regulatory documents?
Location: Dalian, Liaoning, China
Primary positioning: Supplier and exporter of APIs, intermediates, food-related ingredients, and home/personal-care materials
Suitable for: Buyers requiring multi-sector chemical sourcing, pharmaceutical-oriented documentation discussions, or export support
Dalian Handom Chemicals is listed publicly as a China-based supplier of 5-Aminolevulinic Acid Phosphate, described as a medicine-grade powder with 98% purity and a white-to-off-white appearance. Echemi also identifies Handom in relation to 5-ALA Phosphate at 98.0% purity.
The company's broader positioning across APIs, intermediates, vitamins, food-related ingredients, flavors, fragrances, and home/personal-care raw materials can be helpful for procurement teams that manage complex portfolios. Its Dalian base may also suit buyers requiring established export coordination from northeastern China.
Core strengths
- Publicly visible product connection to 5-Aminolevulinic Acid Phosphate.
- Multi-industry sourcing profile, potentially useful for companies with mixed ingredient portfolios.
- Export-oriented supplier positioning.
- Relevant for buyers seeking a higher-documentation conversation than a generic marketplace transaction.
Recommended verification questions
- Does "medicine grade" refer to a formal validated grade, a marketing classification, or a customer-specific specification?
- Is the listed 98% assay a release limit, typical value, or a marketplace approximation?
- Which analytical methods confirm identity and purity?
- What testing is performed for heavy metals, residual solvents, water, and microbial contamination?
- Can the supplier disclose whether the material is produced by fermentation, synthesis, or a mixed process?
Location: Shanghai, China
Primary positioning: Chemical and pharmaceutical raw-material supplier
Suitable for: Buyers looking for a Shanghai-based sourcing contact for chemical and pharmaceutical-material inquiries
Shanghai Pemichem is publicly connected to 5-Aminolevulinic Acid Phosphate through a Made-in-China product page describing "Factory Supply Pharma Raw Material 5-Aminolevulinic Acid Phosphate (ALA), CAS 868074-65-1."
Shanghai remains one of China's most important chemical-trade, life-science, pharmaceutical-services, and international-commercial hubs. For overseas buyers, this ecosystem can make supplier communication, export documentation, sample forwarding, and third-party inspections easier to organize. That said, a product listing alone should never be treated as proof of manufacturing ownership.
Core strengths
- Publicly listed for the target material and CAS number.
- Located in a major life-science and chemical-trade center.
- Potential fit for buyers that value Shanghai-based commercial coordination.
- Relevant for price discovery and technical RFQ comparison.
Recommended verification questions
- Can the company identify the manufacturing plant, legal producer name, and production site?
- Does it control the manufacturing process or purchase from a third party?
- Can it provide a GMP or ISO certificate that matches the exact manufacturing site?
- Can it provide recent batches with traceable lot numbers and release dates?
- What is the standard export packaging, and how is humidity exposure controlled?
Location: China
Primary positioning: High-purity 5-Aminolevulinic Acid Phosphate supplier and manufacturer
Suitable for: Buyers seeking a supplier publicly claiming both manufacturing and high-purity positioning
Conscientia Industrial publicly presents itself as a China-based manufacturer and supplier of high-purity 5-Aminolevulinic Acid Phosphate. Its product page describes fermentation or organic-synthesis pathways combined with phosphate-salt stabilization, with an emphasis on solubility and shelf life.
The company's public explanation is directionally useful because it recognizes that 5-ALA phosphate sourcing involves process route and salt stabilization, not only a commodity grade. Still, buyers should ask for process-specific evidence. A supplier should be able to explain, at an appropriate confidentiality level, whether its material is fermentation-derived, chemically synthesized, or obtained through a hybrid route.
Core strengths
- Explicit public focus on high-purity 5-Aminolevulinic Acid Phosphate.
- Public discussion of production route and phosphate-salt stabilization.
- Potential fit for buyers focused on technical material attributes such as solubility and shelf-life handling.
Recommended verification questions
- Which production pathway applies to the batch being quoted?
- Is the process route consistent across commercial lots?
- What is the material's bulk density, water content, pH range, and storage requirement?
- How is phosphate stoichiometry confirmed?
- Can the supplier provide accelerated and real-time stability data?
Location: China
Primary positioning: Botanical and cosmetic ingredient supplier with a public 5-ALA Phosphate product page
Suitable for: Buyers prioritizing a cosmetic-ingredient context and botanical-active portfolio compatibility
LeSen Bio-technology maintains a public page for 5-Aminolevulinic Acid Phosphate under its cosmetics ingredient category. The page presents the company as a China-based manufacturer and supplier offering bulk purchasing.
The cosmetic-ingredient classification is worth noting because it suggests that the supplier understands how buyers may evaluate the material within a beauty-ingredient portfolio. However, a website category is not equivalent to demonstrating that a particular ingredient has completed market-specific cosmetic reviews.
Core strengths
- 5-ALA Phosphate is publicly placed within a cosmetic-ingredient context.
- Potential relevance for brands integrating the ingredient into broader botanical or functional-active concepts.
- May be a useful candidate for product documentation benchmarking.
Recommended verification questions
- What cosmetic-use dossier can be provided beyond a COA and SDS?
- Are there recommended use levels, solubility data, formulation pH limits, or incompatibility notes?
- Can the supplier provide microbial specifications aligned with the intended finished-product category?
- Does it offer formulation support or only raw powder supply?
- What is its process for managing changes in raw materials, process conditions, or specifications?
Location: China
Primary positioning: Bulk 5-Aminolevulinic Acid Phosphate supplier with publicly stated ≥99% HPLC purity
Suitable for: Buyers initially screening high-assay bulk suppliers
Waycoo Nutritions publicly markets 5-Aminolevulinic Acid Phosphate as a bulk material with ≥99% purity by HPLC. A stated analytical method is more useful than a purity figure without methodology because it creates a starting point for discussing assay, chromatographic conditions, reference standards, and related-substance control.
However, buyers should not assume that "99% by HPLC" answers all quality questions. Depending on the intended use, a raw material with 99% assay may still require review of unknown impurities, residual solvents, water content, elemental impurities, bioburden, and stability after blending or dissolution.
Core strengths
- Publicly stated HPLC assay claim.
- Bulk-supply positioning.
- Suitable for early RFQ comparison, sample qualification, and assay-method discussions.
Recommended verification questions
- Is the HPLC method validated, verified, or simply used internally?
- Can the supplier share representative chromatograms, including impurity peaks?
- Is "≥99%" calculated on an as-is basis or dry basis?
- What is the allowable range for moisture or loss on drying?
- Does the product require nitrogen flushing, desiccant protection, light protection, or temperature-controlled transport?
Location: China
Primary positioning: Nutrition, plant-extract, and functional ingredient supply
Suitable for: Buyers seeking active ingredients within a broader natural-health or nutrition-oriented sourcing portfolio
A Made-in-China listing identifies a 5-Aminolevulinic Acid Phosphate product associated with Focus Health. Because product pages on B2B marketplaces can be created by manufacturers, exporters, agents, or trading businesses, buyers should treat the listing as a lead rather than final proof of production capability.
The supplier may be relevant for buyers already sourcing botanical extracts, nutrition ingredients, or functional compounds from a diversified Chinese ingredient portfolio. It can also serve as a useful pricing and documentation benchmark against more specialized suppliers.
Core strengths
- Public listing of 5-Aminolevulinic Acid Phosphate.
- Potential portfolio overlap with nutrition and plant-derived ingredients.
- Useful as a comparative RFQ source.
Recommended verification questions
- Is the company the producer of the exact material?
- Is the offered grade suitable for cosmetic, nutrition, pharmaceutical, agricultural, or research use?
- What is the source and traceability of each batch?
- Can the company provide an audit package and manufacturing-site information?
- What is the MOQ for evaluation samples, pilot orders, and routine orders?
Location: Shenzhen, Guangdong, China
Primary positioning: Marketplace-listed supplier of Aminolevulinic Acid Phosphate, CAS 868074-65-1
Suitable for: Buyers looking for small-quantity sampling or benchmark quotations
A public Made-in-China listing describes a wholesale supplier offering Aminolevulinic Acid Phosphate, CAS 868074-65-1, with a stated 5 g MOQ, OEM/ODM and sample availability, and a model reference of "SZ-WN."
For R&D teams, a low stated MOQ can be valuable. It may allow initial identity verification, solubility work, compatibility trials, and comparison against existing materials before commercial qualification. However, small MOQ should not be confused with manufacturing scale, quality maturity, or dependable long-term capacity.
Core strengths
- Publicly stated low MOQ for preliminary evaluation.
- Marketplace visibility for sample-stage procurement.
- Potentially useful for early-stage laboratory screening.
Recommended verification questions
- Is the 5 g MOQ for a retained inventory lot or a newly produced commercial-grade batch?
- Can the supplier provide the same specification when the order increases from grams to kilograms?
- Are samples representative of routine commercial production?
- Can the supplier provide retained-sample procedures and lot traceability?
- What are the actual terms for OEM/ODM—relabeling, blending, packaging, or full formulation development?
Location: Henan, Hebei, Shandong, Shanghai, Xi'an, and other regional chemical clusters
Primary positioning: 5-ALA, agricultural biostimulant, chemical intermediate, and functional-ingredient suppliers
Suitable for: Buyers conducting broad supplier mapping, price benchmarking, or multi-route sourcing evaluations
China's 5-ALA ecosystem is not concentrated in only one city. Public marketplace records show suppliers associated with Zhengzhou, Shijiazhuang, Jinan, Shanghai, Xi'an, Wuhan, Dalian, and other locations. These regions serve different industrial strengths:
| Industrial cluster | Typical sourcing advantage | Buyer caution |
|---|---|---|
| Xi’an and Shaanxi | Plant extracts, botanical actives, natural-product R&D, cosmetic ingredients | Confirm the exact 5-ALA phosphate manufacturing route and commercial capacity |
| Shenzhen and Guangdong | Export coordination, consumer-product development, private-label and packaging networks | Verify whether the seller owns the production site |
| Shanghai | Chemical trade, life sciences, global logistics, documentation coordination | Distinguish a commercial agent from the actual producer |
| Zhengzhou and Henan | Agricultural chemicals, plant-growth inputs, general chemical supply | Ensure the material is not agricultural grade or a different 5-ALA salt |
| Shijiazhuang and Hebei | Fertilizer, amino-acid, agricultural and chemical-processing networks | Request intended-use documentation and impurity controls |
| Dalian and Liaoning | Chemical export, pharmaceutical and intermediate supply channels | Confirm manufacturing-site quality systems and batch consistency |
This tenth position is intentionally broader because procurement teams should not rely on a single online ranking. The better approach is to build a qualified supplier pool, issue a technically detailed RFQ, compare documentation quality, and validate the exact batch through independent testing before awarding a long-term supply agreement.
The following table is a practical starting point. "Not publicly confirmed" does not mean a supplier lacks a capability; it means the buyer should request direct evidence rather than assume the information from public marketing materials.
| Supplier | Public product relevance | Reported or stated purity | MOQ indication | Certifications | OEM/ODM or customization focus | Buyer fit |
|---|---|---|---|---|---|---|
| ZHENYIBIO TECHNOLOGY INC | Cosmetic-active and formulation-support positioning | Request batch-specific specification | Discuss by project | GMP-standard factory claim; request current certificate scope | Strong potential for customized cosmetic ingredients, blends, liposomes, and finished-product direction | Brands and distributors seeking flexible technical cooperation |
| Shenzhen Hygieia Biotech | 5-ALA Phosphate, CAS 868074-65-1 | Request current COA | Not publicly confirmed | Request verification | Request confirmation | Buyers seeking a product-specific active-ingredient lead |
| Dalian Handom Chemicals | 5-ALA Phosphate, medicine-grade listing | 98% publicly referenced | Request quotation | Request verification | Primarily supply and export; confirm customization | API/intermediate and multi-sector sourcing |
| Shanghai Pemichem Biotechnology | 5-ALA Phosphate, CAS 868074-65-1 | Request current COA | Request quotation | Request verification | Confirm whether OEM/ODM is available | Shanghai-based sourcing and technical RFQs |
| Conscientia Industrial | 5-ALA Phosphate with process/stability claims | High-purity claim; request data | Request quotation | Request verification | Potential technical specification customization | Buyers focused on process-route discussions |
| LeSen Bio-technology | 5-ALA Phosphate in cosmetic-ingredient category | Request current COA | Request quotation | Request verification | Confirm formulation support | Cosmetic active sourcing |
| Waycoo Nutritions | Bulk 5-ALA Phosphate | ≥99% HPLC publicly stated | Request quotation | Request verification | Confirm customization | Assay-led bulk material screening |
| Focus Health / Focusherb | 5-ALA Phosphate marketplace listing | Request current COA | Request quotation | Request verification | Confirm OEM/ODM scope | Natural-health and functional-ingredient buyers |
| Shenzhen WN / listed supplier | 5-ALA Phosphate marketplace listing | Request current COA | 5 g publicly referenced | Request verification | OEM/ODM and samples publicly referenced; define scope | Laboratory and pilot-stage sourcing |
| Regional specialized suppliers | Mixed 5-ALA and chemical categories | Varies by supplier | Varies | Varies | Varies | Broad market mapping and benchmark sourcing |
Procurement note: Never use "ISO certified" as a complete qualification decision. A certificate may apply to a sales office rather than the manufacturing site, may exclude the product category in question, or may have expired. Always compare the legal company name, factory address, certificate scope, issuing body, certificate number, and expiration date with the supplier's commercial documents.
One of the most common sourcing errors is treating all "5-ALA" materials as equivalent.
Your purchase order, technical agreement, COA, and import documents should clearly state:
- Chemical name: 5-Aminolevulinic Acid Phosphate.
- Alternative name: 5-ALA Phosphate.
- CAS number: 868074-65-1.
- Required grade: Define cosmetic-development, food, pharmaceutical, research, or other applicable grade based on actual intended use.
- Assay method and basis: For example, HPLC assay on as-is or dry basis.
- Appearance: White to off-white powder, if this is part of the approved specification.
- Particle size: Only if relevant to dissolution, processing, or formulation appearance.
- Water content or loss on drying: Define an acceptance limit.
- Microbial specifications: If appropriate for the end-use and market.
- Storage conditions: Such as sealed, dry, protected from light, controlled temperature, or other validated conditions.
- Retest date and shelf life: Supported by real stability data.
A supplier that cannot clearly distinguish 5-Aminolevulinic Acid Phosphate from 5-Aminolevulinic Acid HCl should not move directly to commercial qualification.
At a minimum, serious buyers should request:
- Current specification sheet.
- Batch-specific certificate of analysis.
- Safety data sheet.
- Certificate of origin, if needed.
- Manufacturing-site information.
- Quality-system certificates and scope.
- Allergen statement, if relevant.
- GMO statement, if relevant.
- TSE/BSE statement, if relevant.
- Residual-solvent statement.
- Elemental-impurity or heavy-metal test report.
- Microbial test report where appropriate.
- Stability data or storage recommendations.
- Packaging specification.
- Change-control commitment.
- Statement on animal testing, if relevant to the brand's policy and target market.
For China-market cosmetic projects, ingredient status must be reviewed against the current regulatory framework and relevant standards. The National Medical Products Administration has emphasized continuing development of ingredient safety controls, standard systems, and technical evaluation mechanisms.
A single sample from a supplier should not qualify a commercial ingredient. Use a staged approach:
1. Screening sample: Verify identity, appearance, solubility, odor, pH behavior, and basic formulation compatibility.
2. Pilot-lot sample: Test the material in a representative formulation and packaging system. Conduct stability work under relevant storage conditions.
3. Commercial-lot qualification: Purchase a lot that represents normal commercial supply, then compare its test results against the approved sample and specification.
For critical materials, arrange third-party laboratory verification. The test panel should match the risks of the material and intended product—not simply repeat the supplier's stated assay.
Remote qualification can begin with a video audit, but a factory audit or third-party inspection is preferable before large-scale commitment.
Ask to see:
- Raw-material receiving and quarantine areas.
- Batch records and lot coding.
- Weighing, reaction, fermentation, purification, drying, and packaging areas as applicable.
- Environmental controls.
- Cleaning validation approach.
- Equipment calibration records.
- Retained-sample storage.
- Nonconformance and deviation handling.
- Customer complaint process.
- Finished-product release process.
- Warehouse segregation, humidity controls, and export-packaging procedures.
A good supplier does not need to reveal confidential trade secrets. It should, however, be able to demonstrate that it has controlled processes.
5-ALA Phosphate should not be treated as an ordinary low-value powder when preparing international shipments.
Confirm:
- Whether the product is hygroscopic or light-sensitive.
- Required inner bag, foil bag, desiccant, nitrogen flush, or drum liner.
- Temperature and humidity recommendations.
- Whether air freight or ocean freight is appropriate for the validated shelf life.
- Whether the supplier has export experience to your destination.
- Harmonized System classification, customs declaration, and country-specific import requirements.
- Insurance responsibility under the agreed Incoterm.
- Procedures for temperature excursions, damaged packaging, and customs delays.
China's General Administration of Customs maintains official trade-statistics resources that buyers can use alongside import data services when analyzing macro-level sourcing trends.
This is one of the industry's most overlooked risks.
A polished COA can show an impressive assay result, but it may not represent the lot you will receive six months later. For materials such as 5-Aminolevulinic Acid Phosphate, the real commercial risk often appears when a supplier changes a raw-material source, modifies purification parameters, scales up a batch, switches drying conditions, or substitutes a packaging component.
The critical question is not only:
> "Can you provide a 99% COA?"
It is:
> "Can you provide three recent batch COAs, show the acceptable variability range, explain your change-control process, and commit to notifying us before changes that could affect identity, purity, particle properties, impurities, microbiology, or formulation performance?"
- Request COAs from at least three non-consecutive production batches.
- Compare assay, moisture, related substances, microbial data, heavy metals, and appearance.
- Ask whether the results are from in-house testing, external testing, or both.
- Require notification before material, process, site, test-method, packaging, or specification changes.
- Keep a sealed retention sample from every accepted commercial lot.
- Include acceptance criteria and rejection procedures in the quality agreement.
- Re-test the first commercial shipments through an independent laboratory.
A supplier that welcomes this level of scrutiny is usually more suitable for long-term cooperation than one focused only on price and speed.
China's production advantage is not just lower manufacturing cost. It is supported by interconnected ecosystems in biotechnology, botanical extraction, fermentation, packaging, chemical processing, contract manufacturing, and export logistics.
For cosmetic active ingredients, buyers should view China as a collection of specialized industrial clusters rather than a single uniform market:
- Xi'an and Shaanxi have strong links to plant extracts, natural-product research, and botanical-actives development.
- Shenzhen and Guangdong support fast-moving consumer goods, export logistics, private-label manufacturing, packaging, and product development.
- Shanghai brings chemical-trade networks, life-science services, and international commercial infrastructure.
- Henan, Hebei, and Shandong include large agricultural, chemical, amino-acid, and industrial-material ecosystems, but grade differentiation is especially important.
- Dalian and northeast China offer chemical export and intermediate-supply capabilities.
Demand for more sophisticated cosmetic ingredients is also being shaped by China's expanding beauty market and regulatory evolution. NMPA policy materials emphasize improved controls related to ingredient safety, technical evaluation, and cosmetic standards. For buyers, this reinforces a practical principle: documentation quality and traceability should be treated as part of product quality.
China offers a broad and increasingly capable supply base for 5-Aminolevulinic Acid Phosphate, but buyers should avoid treating this ingredient as a simple commodity. The strongest sourcing decisions come from confirming the exact salt form, verifying the manufacturing entity, reviewing batch-level quality evidence, testing representative samples, and building a quality agreement before scaling up.
For brands, distributors, and formulators that need flexible project communication and broader cosmetic-development support, ZHENYIBIO TECHNOLOGY INC is a relevant first-contact supplier. Its stated focus on natural plant-active cosmetic materials, R&D, GMP-standard production practices, international supply, and customized cosmetic solutions makes it particularly suitable for small-to-medium brands and buyers seeking more than a one-time bulk transaction.
If you are evaluating 5-Aminolevulinic Acid Phosphate for a cosmetic ingredient project, request a complete technical package, batch-specific sample COA, formulation-use guidance, MOQ proposal, lead-time plan, and customized OEM/ODM consultation before approving a commercial order.
Ask for the complete certificate PDF, not a cropped image. Check the legal company name, factory address, certification scope, certificate number, issue date, expiration date, and issuing certification body. Then contact the issuing body or use its official certificate-verification system where available.
Also confirm that the certified site is the actual manufacturing site of 5-Aminolevulinic Acid Phosphate. A trading company's ISO certificate does not automatically validate an upstream plant.
No. HPLC assay is important, but it is only one part of qualification. You should also review identity testing, impurity profile, water content, residual solvents, elemental impurities, microbiological data where applicable, stability, packaging protection, and consistency across multiple lots.
A 99% result can still hide unacceptable variability if the method, basis of calculation, impurity profile, and batch representativeness are unclear.
MOQ varies widely according to supplier type, grade, packaging, available inventory, and customization level. Some marketplace listings indicate very small sample-stage quantities, including a 5 g minimum order for a listed product. That does not mean the same supplier can provide low MOQ at a stable commercial specification.
For new projects, negotiate separate quantities for laboratory samples, pilot batches, first commercial orders, and annual volume commitments.
You should not assume so. Agricultural-grade 5-ALA and cosmetic-development-grade 5-Aminolevulinic Acid Phosphate may differ in salt form, impurity controls, production documentation, microbiological expectations, packaging, and regulatory suitability.
A high assay alone does not establish that the product is appropriate for cosmetic development or legal sale in a destination market.
Do not compare price per kilogram alone. Normalize every quotation against the same specification and commercial conditions:
| Comparison factor | Why it changes the true landed cost |
|---|---|
| Assay basis | A quoted 99% “as-is” material may differ from 99% on a dry basis |
| Salt form and CAS number | 5-ALA phosphate and 5-ALA HCl are not directly comparable |
| Packaging | Moisture and light protection can materially affect product quality |
| Test package | A lower quote may exclude microbial, impurity, or stability testing |
| MOQ | A low unit price may require an impractical minimum quantity |
| Incoterm | EXW, FOB, CIF, DDP, and air-freight terms create different total costs |
| Lead time | Lower cost may come with high delivery uncertainty |
| Documentation | A supplier that cannot support compliance can create expensive delays |
| Change control | Inconsistent future lots can cost more than a higher initial price |
- [National Medical Products Administration — Cosmetics]: Official source for cosmetics-related regulatory notices and ingredient administration information. [english.nmpa.gov]
- [NMPA Policy on Cosmetics Reform]: Official policy material discussing ingredient safety, innovation, standards, and technical evaluation. [english.nmpa.gov]
- [General Administration of Customs of the People's Republic of China — Statistics]: Official customs statistics portal for China trade data. [english.customs.gov]
- [U.S. International Trade Administration — China Consumer Goods]: Market context for China's consumer-goods and cosmetics sector. [trade]
- [Ingredients Network — 5-Aminolevulinic Acid Phosphate Listing]: Public reference identifying 5-ALA Phosphate with CAS 868074-65-1 and molecular formula C5H12NO7P. [ingredientsnetwork]
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