Does Hexapeptide-10 Help Tighten the Skin?

Hexapeptide-10 is the main connecting structure between the basal cells and the underlying basement membrane,which is formed by the irregular protrusion of the dermal side membrane of keratinocytes and the basement membrane band.The four layers of the basement membrane zone:the cell membrane layer, the transparent layer,the dense layer,and the dense lower layer are organically combined through various mechanisms.In addition to the tight connection between the dermis and the epidermis,it also has the functions of permeability and barrier.The stromal membrane separates the epidermis from the extracellular matrix (ECM) located under the dermis.The matrix membrane consists of a basal plate (connected to cells) and a basic reticular layer (connected to the ECM).The basal plate is rich in type IV collagen,proteoglycans and glycoproteins including endokinin and laminin.These molecules are involved in forming the skin scaffold and perform bioadhesive functions in cell attachment.In particular,the laminin sequence contains several domains:collagen type IV, heparan sulfate acetyl proteoglycan,endogenous hormones,and cell surface receptors.Hexapeptide-10 is a glycoprotein with a molecular weight of about 850 kDa, which is the most abundant protein in the ECM except collagen.Hexapeptide-10 is only present in the matrix membrane.It is formed by three long polypeptide chains (¦Á, ¦Â, ¦Ã) asymmetrically crossed and covalently bonded through disulfide bonds.Because each of the three chains has different isoforms,laminin has 15 heterotrimers,of which laminin-5 is the most well-studied.Among the receptors involved in laminin recognition,the most important one is integrin,which was the first ECM receptor to be discovered.Integrins are a group of transmembrane cell surface receptors responsible for cell-cell junctions and cell-ECM junctions.Cells recognize the laminin domain through integrin receptors to tightly bind cellular proteins to the matrix membrane.Hexapeptide-10 is a form of hexapeptide 10, a chain of six amino acids that stimulate cellular activity by interacting with specific molecules.The result is that collagen is rebuilt, fine lines are believed to be reduced and pore size is reduced.According to Lipotec research, Serilesine not only stimulates collagen,but also increases the number of cells (without making them feel traumatized like retinol).

Clinical test 

A number of clinical studies conducted by foreign companies have shown that:20 healthy female volunteers, aged from 55 to 64 years old,with varying degrees of sagging skin,half of the face was treated with hexapeptide-10 containing 0.005%, and the other half of the face was treated with a placebo group. 2 times a day,after 60 days, use half of the face with 0.005% Hexapeptide-10.The skin is firmer, smoother and more elastic,and the skin density is increased by 20%.Hexapeptide-10 is considered so good because it is based on the laminin (Laminin) chain - the second most abundant protein in the skin after collagen,but is buried so deeply that it is often overlooked.According to research by Lipotec,laminin excels in cell migration,cell growth and adhesion.

Hexapeptide-10-Mechanism of Action

Hexapeptide-10 promotes the formation of hemidesmosomes by promoting laminin-5 and ¦Á6-integrin synthesis,enhancing cell adhesion and cell proliferation, resulting in firmer skin while reducing other skin aging phenomena such as dullness Yellowing, inelastic,etc.

Hexapeptide-10-Application

1.Increased synthesis of laminin V and ¦Á6-integrin promotes cell association

2.Very good for skin repair (especially acne marks)

3.Fights skin laxity and makes skin more elastic and firm

4.Helps skin microcirculation

5.Suitable for all kinds of anti-wrinkle and anti-aging, firming repair, postpartum and after-sun body care.