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5-Aminolevulinic Acid Hydrochloride

Product Description

5-aminolevulinic acid hydrochloride is widely used in various scientific fields. The application example is shown below,Increase the yield or increase the green sensitivity of plants; Supplements for animal microorganisms or cell culture.Research on the production of reactive oxygen species from excessive porphyrin accumulation is used for photodynamic diagnosis of cancer.Research on the production of reactive oxygen species from the accumulation of excess porphyrin.

5 ALA hcl Improve the harvest or increase the greenness of plants.In cosmetics,Aminolevulinic acid hydrochloride(5-ALA hcl) used for protecting skin from sun.

Technical Date

TEST ITEM	SPECIFICATION	RESULTS
Appearance	Almost white to off-white crystalline powder	Almost white crystalline powder
Identification	HPLC	Conform
Loss on drying	≤1.0%	0.33%
Melting point	150℃--155℃	151.1℃--152.3℃
Residue on ignition	≤0.5%	0.10%
Heavy metals	≤20ppm	Conform
Iron	≤20ppm	Conform
Bacteria endotoxins	≤0.4 USP EU/mg	Conform
Microbial Limits
Total aerobic microbial count	≤100 cfu/g	Conform
Staphylococcus aureus	Absence	Absence
Pseudomonas aeruginosa	Absence	Absence
Salmonella species	Absence	Absence
Escherichia Coli	Absence	Absence
Impurities
Any other single impurity	≦0.3%	Conform
Total impurities	≦1.0%	0.30%
Assay	98.0%-102.0%	99.86%

FAQ

★Is 5-Aminolevulinic Acid Hydrochloride water-soluble or oil-soluble?

5-ALA HCl is excellent water-soluble, slightly soluble in methanol and ethanol, almost insoluble in oil phase. It is very convenient to use in aqueous solutions and water-based formulations.

★Is 5-Aminolevulinic Acid Hydrochloride water-soluble or oil-soluble? How to incorporate it?

5-ALA HCl is water-soluble. It dissolves readily in water, glycols (propylene glycol, butylene glycol), and glycerin. It has very low solubility in oils. Incorporation method:

For water-based formulas: Dissolve 5-ALA in the water phase at room temperature or with gentle warming (below 40°C).

For anhydrous gels: Pre-dissolve in a small amount of glycol, then mix with other glycols or gelling agents.

Avoid direct addition to hot water (>50°C) to prevent degradation.

We recommend adding 5-ALA during the cool-down phase (below 40°C) after other water-phase ingredients have been processed.

★What is the recommended dosage of 5-Aminolevulinic Acid Hydrochloride in cosmetic formulations?

5-ALA is active at very low concentrations:

Anti-aging / collagen stimulation (with red light): 0.1-0.5%

Anti-acne / sebum control (with blue light): 0.5-2%

Skin brightening / melanin reduction: 0.1-0.5%

Daily maintenance (non-photodynamic): 0.05-0.2%

Do not exceed 2% in leave-on products to minimize phototoxicity risk. For first trials, start at 0.1-0.2%. Higher concentrations require strict light protection instructions.

★What is the role of 5-ALA HCl in cosmetics?

It accelerates skin keratin metabolism, mildly improves aging keratin, brightens dull skin, refines texture, and assists photodynamic skincare effects with mild and non-irritating properties.

★What pH and temperature are suitable for 5-ALA HCl?

Stable in pH 3.0–6.0 (weakly acidic). Avoid high temperature above 60℃ during production and use to prevent activity loss.

★What ingredients can 5-ALA HCl be compounded with?

Agriculture: Amino acids, humic acid, macro/micro elements, seaweed extract

Cosmetics: Hyaluronic acid, niacinamide, VC derivatives, centella asiatica, panthenol

★Can you provide COA, MSDS, TDS documents?

We provide complete COA, MSDS, TDS, heavy metal and microbial reports for global customs clearance and registration.

★What is the difference between 5-ALA HCl and 5-ALA free base?

5-ALA HCl has better stability, higher water solubility and easier storage; 5-ALA free base is unstable and difficult to store. HCl salt is more suitable for industrial and commercial applications.

Tel：+8615309206328

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E-mail： alexxue@zhenyibio.com

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How does ZHENYIBIO ensure the oxidative stability of whitening actives in water-based formulations?

We have developed a proprietary Anti-oxidation Stabilization System specifically designed for oxidation-prone active ingredients (such as glutathione). By controlling residual heavy metals in the raw materials—the primary catalysts for oxidation—and recommending a complementary chelating agent regimen, we ensure that the ingredients remain free from browning over extended periods within a pH range of 5.0 to 7.0.

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For large-molecule plant-derived active ingredients, we employ Liposomal Encapsulation and Micronization technologies. These techniques significantly reduce particle size, enabling active ingredients—such as Alpha-Arbutin—to more easily penetrate the stratum corneum and reach the areas where melanocytes are concentrated.

Can you provide In-vitro or In-vivo efficacy data for your whitening product line?

Yes. In addition to providing standard TDS documents, we can—upon request—supply data from Tyrosinase Inhibition Tests as well as Human Patch Test reports to support clinical claims regarding the "whitening efficacy" of your finished products.

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