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Silk Fibroin

Product Description

Silk fibroin (silk protein hydrolysate) is a natural moisturizing factor (NMF) with the amino acid content of silk protein,which can beneficially rebuild the skin's moisturizing system.

Silk fibroin serum is known for its excellent moisturizing and anti-aging properties,as well as soothing and antioxidant effects.Silk fibroin hydrogel has a significant antioxidant effect and forms a protective peptide coating to protect the skin from harmful effects.It retains moisture and provides a soft touch.The silk fibroin film was developed to accelerate wound healing and can be peeled off without damaging the newly formed skin.

Technical Date

ITEM	SPECIFICATION	TEST METHOD
Appearance	white or light yellow powder	Sensory test
Dissolvable Level	Liable to dissolve	/
Nitrogen	≥14.5%	Kjeldahl method
PH (5% Aqueous Solution)	5.00-7.50	QB 2732-2005
Ash	≤4.0%	GB/T 5009.4
Loss on drying	≤4.0%	GB/T 5009.3
Pb	<0.5 PPM	GB 5009.12
As	<0.5 PPM	GB/T 5009.11
Hg	<0.5 PPM	GB/T 5009.17
Cr	<2.0 PPM	GB/T 5009.123
Total Plate Count	<1000cfu/g	GB/T 4789.2
Mold & Yeast	≤50 CFU/g	GB/T 4789.15
E.Coli	≤0.4 MPN/g	GB/T 4789.3
Salmonella	Negative	GB/T 4789.4

FAQ

★What is Silk Fibroin?

Silk Fibroin is a natural protein extracted from silk, mainly composed of glycine, alanine and serine. It has good biocompatibility, moisture retention and film-forming properties, and is widely used in cosmetic formulations.

★What are the main cosmetic benefits of Silk Fibroin?

It can lock skin moisture, improve skin dryness and roughness; form a thin protective film on the skin surface to resist external irritation; help repair damaged skin barrier; and has a mild texture, suitable for sensitive skin.

★What is the solubility of Silk Fibroin for cosmetic formulation?

It is highly water-soluble, easy to dissolve in deionized water, and insoluble in oil. It is suitable for water-based formulations such as lotions, serums, masks and toners.

★Is Silk Fibroin allowed to be used in cosmetics in major regions (China, EU, US, South Korea, Japan)?

- China: Included in the Catalogue of Used Cosmetic Ingredients (2021 Edition);

- EU: Compliant with Cosmetics Regulation 1223/2009;

- US: Recognized as safe by FDA, compliant with MoCRA regulations;

- South Korea: Reportable to MFDS for circulation;

- Japan: Permitted, compliant with Pharmaceutical and Medical Device Law.

★What formulation considerations should be paid attention to when adding Silk Fibroin?

Control pH at 4.5-6.5; avoid high temperature (>80℃) and strong oxidants; control concentration (0.5%-5% for leave-on, 1%-40% for rinse-off); match appropriate preservatives; adjust texture to avoid stickiness.

★Is Silk Fibroin safe for sensitive skin?

Yes. It is a natural protein with mild properties, no obvious irritation, and can reduce skin sensitivity, making it suitable for sensitive and fragile skin types.

★Can Silk Fibroin be mixed with other cosmetic ingredients?

It is compatible with most water-soluble ingredients (humectants, preservatives, water-soluble vitamins), but incompatible with strong oxidants and cationic surfactants (may cause precipitation).

★Which well-known cosmetic brands use Silk Fibroin?

Several well-known international and Asian cosmetic brands, including Tatcha, Swissline, Kallos Cosmetics, INOHERB, Si An Yan, BOSIROU and Siusuelle, use Silk Fibroin in their skincare and haircare products for its moisturizing, soothing, anti-aging and other benefits.

★What formulation considerations should manufacturers pay attention to when adding Silk Fibroin?

When adding Silk Fibroin, manufacturers should focus on its high purity (low impurities like sericin, consistent molecular weight), optimize solubility/dispersion to avoid aggregation, ensure compatibility with co-ingredients, and tune its structure for target degradation/mechanical properties.

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FAQs

How does ZHENYIBIO ensure the oxidative stability of whitening actives in water-based formulations?

We have developed a proprietary Anti-oxidation Stabilization System specifically designed for oxidation-prone active ingredients (such as glutathione). By controlling residual heavy metals in the raw materials—the primary catalysts for oxidation—and recommending a complementary chelating agent regimen, we ensure that the ingredients remain free from browning over extended periods within a pH range of 5.0 to 7.0.

Are your botanical brightening extracts compatible with high-concentration electrolytes?

Our plant extracts undergo a multi-stage refining process to remove the majority of inorganic salts and impurities; as a result, they exhibit excellent compatibility within serum formulations containing thickeners or high concentrations of electrolytes, without giving rise to flocculation or phase separation.

What technologies does ZHENYIBIO use to improve the skin penetration of plant-derived actives?

For large-molecule plant-derived active ingredients, we employ Liposomal Encapsulation and Micronization technologies. These techniques significantly reduce particle size, enabling active ingredients—such as Alpha-Arbutin—to more easily penetrate the stratum corneum and reach the areas where melanocytes are concentrated.

Can you provide In-vitro or In-vivo efficacy data for your whitening product line?

Yes. In addition to providing standard TDS documents, we can—upon request—supply data from Tyrosinase Inhibition Tests as well as Human Patch Test reports to support clinical claims regarding the "whitening efficacy" of your finished products.

Do ZHENYIBIO whitening ingredients meet the regulatory requirements of EU and North America?

Fully Compliant. Our products strictly adhere to both EU (Regulation EC No 1223/2009) and US MoCRA standards. A complete Certificate of Analysis (COA) is provided for every batch of raw materials, ensuring that levels of heavy metals, microbial contaminants, and residual solvents remain well below international regulatory limits.

Are your products "Clean Beauty" compliant (Vegan, Non-GMO, Cruelty-Free)?

Yes. As experts in Natural Plant Actives, we pledge that all our ingredients are derived from sustainable plant sources, contain no animal-derived components, involve no animal testing, and are accompanied by comprehensive traceability statements—empowering your brand to enter the clean beauty sector.

How do you guarantee a stable supply of botanical raw materials regardless of seasonal changes?

ZHENYIBIO maintains its own proprietary botanical cultivation bases. Through controlled environments and standardized harvesting processes, we are able to not only guarantee year-round stock availability but also ensure a high degree of consistency in the content of active ingredients—such as Glabridin—across different production batches.

Can ZHENYIBIO develop customized ingredient concentrations for specific brand requirements?

We can provide customized Standardized Extracts tailored to our clients' specific needs. Whether you require high-purity active monomers or blended ingredients in specific ratios, our R&D laboratory is equipped to make precise adjustments to meet your exact formulation requirements.