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10-HDA benefits introduction

Views: 22     Author: Site Editor     Publish Time: 2022-03-23      Origin: Site

The main ingredients of royal jelly are water, crude protein, crude fat and decenoic acid (10-Hydroxy-δ-2-Decenoic Acid, referred to as 10-HDA). The decenone is the most important organic acid in the royal jelly, which helps to increase the immune system. According to German and French scholars, 10-HDA contained in the royal jelly can enter cymocytes and stimulate them to kill viruses, such as caused frostbite, genital disease herpes virus and hepatitis virus. In medicine, the royal jelly does still improve physical fitness, treat diseases, activated cells to prevent aging, antibacterial antibacterial and enhanced memory.

The characteristics of 10-HDA

When you taste the royal jelly, the spicy taste is from 10-HDA, and the more spicy 10-HDA content is more. In addition, 10-HDA is more important indicators that discriminate the quality or effectiveness of the royal jelly, in Japan, according to the fair competition Regulations, health food consumption of 10-HDA content, in recent years, more than 1.6%; Taiwan National Standards Bureau in 1988 The official GB9697-88 standard was issued, and it was booked at 1.4%, but the unit of the general folk grassroots acquisition of the bee jelly was booked at 1.6%.dha dihydroxyacetone - ZHENYIBIO

The researchers finally found that 10-HDA is an important substance with immune function, antibacterial, anti-inflammatory, anti-tumor, protecting blood brain barrier, and resisting skin injury.

The cyclophosphamide is a drug inhibiting animal immune function, and the immune function of the injection of 10-HDA, the immune function of the mice can be restored by the injection of cyclophosphamide, and the spleen is also repaired.

Royal jelly (RJ) produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan of Caenorhabditis elegans. The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA.

10-HDA further extended the lifespan of the daf-2 mutants, which exhibit long lifespan through reducing insulin-like signaling (ILS), indicating that 10-HDA extended lifespan independently of ILS. On the other hand, 10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan through dietary restriction caused by a food-intake defect. This finding indicates that 10-HDA extends lifespan through dietary restriction signaling. We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15, which encodes Raptor, a target of rapamycin (TOR) components, indicating that 10-HDA shared some longevity control mechanisms with TOR signaling.

Additionally, 10-HDA was found to confer tolerance against thermal and oxidative stress. 10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C. elegans.

It has been reported that lifespan is regulated mainly through insulin-like signaling (ILS) and dietary restriction signaling in C. elegans as well as Drosophila melanogaster and other experimental animals. In the present study, we found that 10-HDA extended the lifespan of C. elegans not through ILS but through dietary restriction signaling. Dietary restriction signaling has been reported to mediate lifespan extension through various downstream signaling pathways including target of rapamycin (TOR) signaling. We suggest in this report that 10-HDA extends the lifespan via the TOR signaling.