Views: 1 Author: Site Editor Publish Time: 2023-03-16 Origin: Site
For a long time, whitening ingredients have emerged in an endless stream, such as niacinamide, arbutin, resveratrol, phloretin, ferulic acid, tetrahydrocurcumin, vitamin C and its derivatives, kojic acid, etc.Among these whitening ingredients, some ingredients are famous, but their effect is not outstanding.Some ingredients, such as resorcinol derivatives, fruit acids, salicylic acid, etc.,work well but are irritating to the skin.Glabridin as an effective skin lightening agent with many benefits.
Glabridin Skin Whitening Effect
Glabridin's whitening mechanism is comprehensive.First, it inhibits tyrosinase and dopachrome tautomerase, the main forces in production.When the main force is weakened, the production of melanin will naturally come down.In addition, glabridin can relieve inflammation and inhibit inflammatory factors.Inflammatory factors are one of the main factors leading to melanocyte production. If inflammatory factors are controlled, melanin production will naturally decrease. Finally, it has antioxidant properties. Antioxidant is good for skin whitening and anti-aging.Adding the three functions together, the whitening effect is natural and powerful.
Whitening Mechanism of Glabridin
Inhibit the activity of tyrosinase and DOPAchrome tautomerase:
The synthesis of melanin mainly involves three enzymes in the tyrosinase gene family, namely tyrosinase (TYR), DHICA oxidase (TRP-1), and dopachrome tautomerase (TRP-2).Tyrosinase is the key enzyme for this reaction.TYR is involved in the production of pheomelanin and eumelanin, while TRP-2 and TRP-1 play an important role in the synthesis of eumelanin.The synthesis of melanin mainly goes through two stages.The first stage is the generation of dopaquinone from tyrosine under the catalysis of tyrosinase.The reaction at this stage is a key step in the synthesis of melanin.Dopaquinone, as the substrate of melanin synthesis, enters the second stage of the reaction. If dopachrome tautomerizes under the action of TRP-2 to dihydroxyindole-2-carboxylic acid (DHICA), eumelanin is formed under the action of TRP-1.Therefore, inhibiting the activity of tyrosinase and TRP-2 is considered to be an important method to inhibit pigmentation.In 1998, Kanebo Institute of Basic Science and Cosmetics conducted research on the effect of glabridin on melanin production.In an in vitro test in guinea pigs, different concentrations of glabridin were added to the culture medium of B16 melanoma cells to determine the amount of HO released.Therefore, 0.1-10 μg/mL glabridin inhibited tyrosinase activity in a concentration-dependent manner.The results also showed that the UVB-induced back pigmentation of guinea pigs was significantly reduced due to continuous application of 0.5% glabridin for 3 weeks.In the same year, Kose also conducted research on the effects of glabridin on melanin production and TRP-2.In vitro, Glabridin inhibits TRP-2 activity at very low concentrations and inhibits TRP-2 activity in a concentration-dependent manner.
Post-inflammatory hyperpigmentation is a clear sign of skin damage.This is an inflammatory response.Any injury can cause it to happen, such as rubbing, rubbing, wounds, dermatitis, rashes, acne, UV rays, laser treatments, etc.Glabridin 0.05% showed significant anti-inflammatory effects from the beginning of irradiation.Six hours after irradiation, the skin pretreated with glabridin recovered faster than the control group, returning to its pre-irradiation state.Therefore, glabridin can reduce skin inflammation caused by ultraviolet rays.
In addition to inhibiting tyrosinase activity, glabridin also has good free radical scavenging and antioxidant effects.From the perspective of anti-oxidation, glabridin showed good anti-oxidation effects both in vivo and in vitro.We know that exposure of the skin to UV rays can cause some reactions (such as inflammation).Because the phospholipid membrane of skin tissue is damaged by active oxygen induced by ultraviolet rays.This histological change manifests as erythema and hyperpigmentation.Glabridin has a strong ability to remove DPPH and OH in a dose-dependent manner.It has excellent in vitro antioxidant activity.The test results show that glabridin has the similar ability to scavenge oxygen free radicals as SOD.