The argireline's mechanism, application and usage

What is argireline?

Argireline, also known as acetyl hexapeptide-8, is an oligopeptide that mimics the N-terminus of SNAP-25 protein and consists of six amino acids. Since akirelin is a scientifically and reasonably designed anti-wrinkle active raw material polypeptide based on modern biochemical mechanism, it has become a popular cosmetic raw material for anti-wrinkle in the world. Anti-wrinkle. Its efficacy is comparable to that of botulinum toxin type A, but it avoids the disadvantages of botulinum toxin, which must be injected and used.

Argireline mechanism of action

By inhibiting the synthesis of SNARE receptors, inhibiting the excessive release of catecholamines and acetylcholine in the skin, partially blocking nerve transmission of muscle contraction messages, relaxing facial muscles, and achieving the purpose of smoothing fine lines. Especially suitable for application to areas where the muscles of expression are concentrated (the corners of the eyes, the face, the forehead).

Application of argireline

1) Reduce the depth of wrinkles caused by the contraction of facial expression muscles, especially around the forehead and eyes.

2) A safer, cheaper, milder alternative to botulinum toxin that works topically to target wrinkle-forming mechanisms in a special way.

3) Add to cosmetic formulations such as lotions, gels, etc., so as to achieve the ideal effect of removing deep wrinkles or wrinkles around the forehead or eyes.

Usage and dosage of argireline

Anti-wrinkle peptides can be used as a product of akirelin powder (powder can be easily dissolved in water), or as a product of akirelin solution (containing 0.5g/L of powder in the aqueous solution), which can be used in the final stage of cosmetic production. Add Acrelin solution, the preparation temperature should be lower than 40 ℃. Based on the concentration of akirelin solution, 3-10% of the final product is finally recommended to obtain significant anti-wrinkle activity.

Storage and shelf life of argireline

Acrelin solution must be stored in a cool, dark and clean place to ensure a shelf life of at least 12 months. For long-term storage, it is recommended to store at -20°C, and the shelf life can be extended to at least 18 months.