Rosmarinic acid efficacy and application fields

Rosmarinic acid is a water-soluble natural phenolic acid compound extracted from rosemary, so it is named Rosmarinic acid. Not only rosemary, rosmarinic acid is widely found in many plants of Labiatae, Lithospermum, Cucurbitaceae, Tiliaceae and Umbelliferae, especially in Labiatae and Lithospermum.

Effect of rosmarinic acid

1. Antioxidant effect

Rosmarinic acid has a strong activity of scavenging free radicals and antioxidation. The results showed that the mechanism was that rosmarinic acid and unsaturated fatty acid competitively combined with lipid peroxy group to stop the chain reaction of lipid peroxidation and reduce the rate of lipid peroxidation, while rosmarinic acid was oxidized to quinone form. Rosmarinic acid can inhibit the respiratory burst of neutrophils and the release of lysosomes by reducing the intracellular calcium concentration; Inhibits the oxidation of low-density lipoprotein regulated by endothelial cells. The antioxidation of rosmarinic acid is related to its structure. Studies have shown that o-diphenol hydroxyl is the material basis for scavenging free radicals. Moreover, the conjugated double bond at C3 position has a synergistic effect.

2. Antidepressant effect

3. Antibacterial effect of rosmarinic acid

Rosmarinic acid has broad-spectrum antimicrobial activity, and has an inhibitory effect on bacteria and fungi. Rosmarinic acid has obvious inhibitory effect on Bacillus subtilis, Micrococcus luteus, Escherichia coli, Staphylococcus aureus and Ralstonia solani.

It is scientifically found that rosmarinic acid can inhibit the growth and biofilm formation of streptococcus caries and streptococcus mutans, and reduce their glucosyltransferase activity, indicating that rosmarinic acid can be used for the prevention and treatment of oral diseases. The study on antibacterial mechanism of rosmarinic acid shows that rosmarinic acid can increase the permeability of bacterial cell membrane, cause a large amount of leakage of sugars and proteins, and affect the normal metabolism of bacteria; On the other hand, it can also affect the protein metabolism of bacteria and inhibit Taq DNA polymerase.

(1) Bacterial inhibition: Rosmarinic acid has significant inhibitory effect on Bacillus subtilis, Pseudococcus sanguis and Escherichia coli.

(2) Fungus inhibition: the inhibitory activity of rosmarinic acid on the mycelial growth and spore germination of different plant pathogenic fungi.

(3) Inhibition of mold: rosmarinic acid extracted from plants can inhibit phytophthora and its spores, which cause soil borne diseases, and effectively reduce the germination of zoospores.

4. Anti inflammatory effect of rosmarinic acid

(1) Anti nephritis effect: Rosmarinic acid can inhibit the proliferation of glomerular mesangial cells and glomerular expansion.

(2) Anti hepatitis effect: Rosmarinic acid can reduce the liver injury induced by lipopolysaccharide (LPS) and significantly inhibit the increase of plasma transaminase level, which proves that the liver protection effect of rosmarinic acid is through the elimination or reduction of superoxide or oxidation of nitrite rather than through the inhibition of TNF - α Resulting from.

(3) Anti pneumonia effect: Rosmarinic acid inhibits the lung injury characterized by neutrophil retention and interstitial edema induced by diesel exhaust particles.

(4) Anti arthritis effect: Rosmarinic acid can inhibit collagen induced arthritis and significantly reduce the number of arthritis and affected joints.

(5) Anti periodontitis effect: Rosmarinic acid can inhibit the formation of bacterial plaque, thus preventing chronic gingivitis.

(6) Anti dermatitis effect: Rosmarinic acid can relieve atopic dermatitis, also known as atopic eczema or hereditary allergic eczema.

5. Antiviral effect of rosmarinic acid

(1) Anti herpesvirus: Rosmarinic acid shows special activity to herpes simplex virus type I and type II, and is an effective ingredient for controlling herpes disease. Its antiviral activity can not only inhibit the activity of some enzymes in the life cycle of the virus, but also quickly combine with the viral coat protein, thus inactivating the virus.

(2) Anti HIV: Rosmarinic acid can inhibit the activity of HIV - 1 (human immunodeficiency virus 1) integrase.

(3) Anti encephalitis virus: Rosmarinic acid can reduce the mortality of mice with Japanese encephalitis virus, significantly reduce the viral load, and make the virus difficult to spread.

Application of rosmarinic acid powder

Rosmarinic acid is a natural antioxidant with strong antioxidant activity. Its antioxidant activity is stronger than vitamin E, caffeic acid, chlorogenic acid, folic acid, etc. It helps prevent cell damage caused by free radicals, thus reducing the risk of cancer and atherosclerosis. Moreover, rosmarinic acid also has antibacterial, anti-virus and anti-tumor activities. Therefore, rosmarinic acid plays an important role in various fields and is widely used in food, health products and cosmetics.

1. Food field

Rosmarinic acid, as a natural and efficient antioxidant, can replace BHA and BHT and be used in animal and vegetable fats, dairy products, oil rich foods, candy and baked foods; It can also be used as spice in various soups and flavoring foods; It also has antiseptic and antibacterial effects. In Japan, perilla extract rich in rosmarinic acid is used as a decoration to improve the shelf life of fresh seafood.

2. Health products

It has anti-tumor, anti hepatitis and liver injury protection effects, anti nephritis, anti thrombosis and anti platelet aggregation effects, as well as refreshing and refreshing effects, enhancing memory, improving tension and sleepiness.

3. Cosmetics

Used in skin care products, it can remove color spots, resist oxidation, increase skin elasticity, and delay aging; Used in shampoo and hair care products, it can promote scalp blood circulation, improve hair loss, reduce the occurrence of dandruff, stimulate hair growth, and moisturize hair. Therefore, rosmarinic acid can be used as an excellent additive in cosmetics.