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Centella asiatica has been used in traditional herbal medicine in Asia. The whole herb is used, and the dosage forms include encapsulation, decoction and tincture. The active ingredients include triterpene saponins and significant amounts of madecassoside, madecassoside and madecassoside acid. A mouse study showed that this crude herb has anti-inflammatory and analgesic effects.
Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. Asiaticoside is used to study potential treatments for wounds and burns.Asiaticoside is a triterpene found in Centella asiatica. It has anti-inflammatory, neuroprotective, cognitive enhancement, antipyretic, antioxidant, angiogenesis, anti-cancer chemotherapy and chemopreventive activities.
Madecassoside inhibits melanin production by reducing the DNA binding of MITF; therefore, it is occasionally used in skin whitening treatments. In animal models of breast cancer, asiaticoside induces apoptosis, increases the activation of caspase 3, reduces the release of TNF-α and IL-1β, and inhibits the development and size of tumors. In animal models of cerebral ischemia/reperfusion, asiaticoside can improve memory and learning deficits, and reduce the levels of IL-6, TNF-α and IL-1β. In addition, asiaticoside reduces LPS-induced inflammation and fever in the body, inhibits the activity of myeloperoxidase, and increases the activity of heme oxygenase 1 (HO-1). This compound also supports wound healing activity and increases cell migration, attachment and growth in vitro.
Asiaticoside has been shown to down-regulate the expression of TGF-β1 mRNA and tissue inhibitor of metalloproteinase-1, and up-regulate the expression of TGF-β3 mRNA, thereby having the ability to decompose type I collagen products and reduce hypertrophic scars.
Centella asiatica is a medicinal plant widely used in South Asia. C. asiatica extract has therapeutic applications, especially in neuroprotection and wound healing. In addition, its extracts are also widely used to treat inflammatory skin diseases, including leprosy, lupus, varicose ulcers, eczema, atopic dermatitis and psoriasis. Centella asiatica extract is mainly administered as a titrated extract. Centella asiatica titrated extract (TECA) contains Asiatic acid, Asiaticoside and Asiatic acid. In dermatology, these ingredients are used to achieve preventive and therapeutic effects. Asiaticoside prevents ultraviolet A-dependent photoaging by inhibiting the production of reactive oxygen species induced by ultraviolet A. In addition, Asiatic acid, Asiatic acid and Asiaticoside induce collagen I synthesis.
Asiaticoside in C. asiatica has wound healing ability by increasing angiogenesis and collagen formation.Madecassoside enhances the tensile strength of new skin and promotes wound healing.
It also prevents inflammatory processes,which may increase capillary permeability and cause abrasions and hypertrophy.In the laboratory, antioxidant levels were observed on an animal to study the effect of asiaticoside,which plays a key role in wound healing.Researchers studied the effects of asiaticoside on delayed and normal wound healing.In the study,it was observed that the topical use of 0.2% asiaticoside solution resulted in an increase in collagen content,a 57% increase in tensile strength,and a 56% increase in hydroxyproline,and good epithelial formation in guinea pig perforated wounds.
However,the healing of streptozotocin diabetic rats is delayed,so topical application of 0.4% asiaticoside solution to punching damage can increase tensile strength, epithelial formation, hydroxyproline and collagen content through smooth healing.The oral and topical administration of alcohol extract of C.
Asiaticoside has been studied in the laboratory.The oral dose of asiaticoside in guinea pig granules is 1 mg/kg, and the dose in chicken wounds is 40 μg/plate.Compared with the control group, the wounds treated with the extract were more epithelialized and the wounds contracted faster.These results indicate that Centella asiatica has different effects on different stages of scar repair in normal and delayed healing models.