Views: 6 Author: Site Editor Publish Time: 2022-06-13 Origin: Site
Betulinic Acid exists in the plant world, with five plus family (thorns of five plus roots), birch family (birch skin, hanging branches birch bark, beauty of sweet birch bark, beauty and sweet birch bark, beauty birch bark, sweet birch bark, and sweet birch bark. Rosemary, Yunnan licorice, jujube, etc. all contain a certain amount of Betulinic Acid. The current Betulinic Acid is mainly extracted from the birch bark.
CTFA uses Betulinic Acid as cosmetics raw materials, and the 2010 version of the "Chinese Cosmetics Standard Chinese Name Catalog" in the China Expo -Chemical Association. Intellectual reports that have not been used for external use unsafe.
Betulinic Acid can selectively kill human melanoma cells without killing healthy cells. Betulinic Acid has a inhibitory effect on HIV-1 infection. In addition, recent studies have shown that Betulinic Acid to brain tumor, neurotraysic tumor, leukemia, leukemia, leukemia Eliminating malignant tumor cells also have inhibitory effects.
1. Cytic activity. The LD50 of CO-115 for human colon cancer cells is 0.375 μg/ml. It has a strong inhibitory effect on P388, and its ED50 is 5.2 μg/ml. ED50 (μg/ml): L1210 (16.43), HL60 (2.41).
2. Selectively inhibit human melanoma. Fully inhibit the growth of thymoma -free mouse tumors with melanoma and non -toxicity. It is now developing clinically.
3. It has spasm for rats' base tissue.
4. Anti -inflammatory effect. In vitro in vitro, prostaglandin synthesis, IC50 is 101 μm (the controlled aspirin is 1897 μm). Inhibit the foot swelling of mice induced by corner fork-collapse, 5-hydroxylidin, inhibit the ears of mice induced by TPA and EPP.
5. Anti -HIV. Inhibit HIV replication in H9 lymphocytes, EC50 is 1.4 μm. The IC50 that suppresses HIV lymphocytes that is not infected with HIV is 13 μm, and the treatment index is 9.3.
6. The protein kinase CAK, CA2+dependent protein kinase CDPK and phospholipid dependent protein kinase C (PKC) that inhibit CAMP dependencies, IC50 (μm) is 45, 84, and 145.
7. Anti -tumor activity
The earliest research report is that BA has a strong selective cytotoxicity for melanoma cells. The IC50 value is 0.5 to 4.8 mg /ml. More importantly, this study also shows the internal effect of BA. Mel-2 of tumor cells, abdominal injection of 50, 250 or 500mg/kg ba to produce efficient tumor growth inhibitory, and the host cells do not have any toxic signs of toxicity.
Leopoldo C and others have studied BA's selectivity of tumor cells and found that their selective toxicity of tumor cells is very high, which is about 5-7 times that of normal cells. In recent years, it has been found that BA has a more wide range of active effects on other tumor cells, such as gel celloma, neuroblastoma, neuroplastin cell tumor, Ewed tumor, and other malignant tumors, colon cancer, breast cancer, lung cancer , Liver cancer, prostate cancer, kidney cells, ovarian or cervical cancer and leukemia have strong inhibitory effects. In addition to its strong anti -tumor activity in various cancer cell lines, some studies have shown that BA can inhibit the growth of tumor in the body.
8. Anti -HIV activity
One of BA's most prominent biological activity is antiviral activity, especially with AIDS (HIV) activity. Due to the occurrence of HIV drug resistance and long -term drug treatment, it is more difficult to treat AIDS. At present, finding and discovering active ingredients from natural products, and using it as a pilot to carry out structural modification and transformation, is an important strategy for new anti -HIV drug research and development. The derivative study of BA optimized anti-AIDS activity. The first BA derivative that was reported to show great anti-AIDS activity was RPR103611. 1 In vitro experiments, IC50 values ??were found between 40 and 100 nmol/L. The cells that can prevent HIV-1 infection and unintentional CD4 cells are formed. HIV-1 effect.
Betulinic Acid is suppressed to Golden Polygalius, Epidermiococcus, Vibrobacteria, and Vibrio Bacteria, and Bacillus Bacillus. The concentration is 1 μg/ml. Essence
9. Anti -inflammatory activity
Most five -yuan rings triterlagous compounds have anti -inflammatory properties include Betulinic Acid and birch glycol. The anti -inflammatory properties of these two compounds have been verified in a large number of in vitro and in vivo model systems. The results show that birch glycol and birch golf acid have mild anti -inflammatory resistance at higher concentrations, and their anti -inflammatory properties are mainly due to the suppression of non -neurological paths. The result of the interaction of glucocorticoid receptors, but the whole process of endogenous anti -inflammatory protein also plays an important role.
10. Other activity
Betulinic Acid can inhibit malignant malaria, and also has analgesic, insect repellent, anti-HSV-1, anti-ulcer and other activity.
White Betulinic Acid has a whitening skin: Low -concentration Betulinic Acid can be used as a conditioner conditioning assistant, and it can be used to promote the production of cortex collagen with ascorbic acid; Data said that Betulinic Acid has anti -inflammatory and inhibit skin allergies, and the use of high SPF sunscreen can reduce the stimulation of the skin.