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Gallic acid powder is a phytochemical derived from various herbs and has anti-fungal,anti-viral and anti-oxidant properties. Gallic acid is tannin,a kind of astringent ingredient.It makes the skin look firmer,tighter and less porous.Uses: It has powerful antioxidant,anti-inflammatory,anti-microbial and anti-cancer activities.According to reports,the most fascinating benefit is used for on the skin as a skin lightening and skin lightening ingredient.
Gallic acid in the treatment of UV-induced skin photoaging:
The mechanisms by which GALLIC ACID protects skin from UV-induced skin damage are multifaceted. Available evidence suggests that GALLIC ACID reduces UV-induced production of matrix metalloproteinases, thereby reducing collagen degradation. In addition, GALLIC ACID up-regulated Nrf2 (Nrf2 is a transcription factor that controls the expression of several genes encoding antioxidant proteins and cytoprotective mechanisms). Evidence on the effectiveness of GALLIC ACID in preventing photodamage is limited (see table below). A recent study showed that topical treatment of GALLIC ACID (10 μmol/L) in SKH-1 hairless mice resulted in fewer skin wrinkles after 8 weeks of exposure to UVB compared to untreated mice .
Gallic acid improves pigmentation:
Tyrosinase is a copper-containing enzyme that is key to the production of melanin. GALLIC ACID inhibits tyrosinase through active-site copper chelation, thereby reducing the formation of melanine. 2 in vivo studies suggest that GALLIC ACID may be effective in treating hyperpigmentation. Shimogaki et al reported that topical application of GALLIC ACID (1% w/v) improved UV-induced hyperpigmentation within four weeks; Yoshimura et al demonstrated that oral administration of GALLIC ACID-rich pomegranate extract (100 mg/kg/day) vs 1000 mg/kg/day) inhibited UV-induced hyperpigmentation in a dose-dependent manner in brown guinea pigs.
In addition, several human clinical trials have also tested the effectiveness of GALLIC ACID in treating hyperpigmentation. A randomized, double-blind, placebo-controlled trial found that oral administration of GALLIC ACID-rich punicic acid tablets (100-200 mg/day) significantly inhibited hyperpigmentation in subjects with mild sunburn from UV exposure. In a randomized, open-label study, Ertam et al compared the efficacy of synthetic 1% GALLIC ACID, naturally derived 1% GALLIC ACID, and 1% arbutin in the treatment of melasma. Both formulations of GALLIC ACID are as effective as the well-known lightening agent arbutin in improving pigment density. - A recent study reported that combination therapy of topical 0.5% GALLIC ACID and 0.1% salicylic acid was as effective as 4% hydroquinone in improving several clinical and instrumental measures of pigmentation.
Gallic acid powder is a phytochemical derived from various herbs and has anti-fungal,anti-viral and anti-oxidant properties. Gallic acid is tannin,a kind of astringent ingredient.It makes the skin look firmer,tighter and less porous.Uses: It has powerful antioxidant,anti-inflammatory,anti-microbial and anti-cancer activities.According to reports,the most fascinating benefit is used for on the skin as a skin lightening and skin lightening ingredient.
Gallic acid in the treatment of UV-induced skin photoaging:
The mechanisms by which GALLIC ACID protects skin from UV-induced skin damage are multifaceted. Available evidence suggests that GALLIC ACID reduces UV-induced production of matrix metalloproteinases, thereby reducing collagen degradation. In addition, GALLIC ACID up-regulated Nrf2 (Nrf2 is a transcription factor that controls the expression of several genes encoding antioxidant proteins and cytoprotective mechanisms). Evidence on the effectiveness of GALLIC ACID in preventing photodamage is limited (see table below). A recent study showed that topical treatment of GALLIC ACID (10 μmol/L) in SKH-1 hairless mice resulted in fewer skin wrinkles after 8 weeks of exposure to UVB compared to untreated mice .
Gallic acid improves pigmentation:
Tyrosinase is a copper-containing enzyme that is key to the production of melanin. GALLIC ACID inhibits tyrosinase through active-site copper chelation, thereby reducing the formation of melanine. 2 in vivo studies suggest that GALLIC ACID may be effective in treating hyperpigmentation. Shimogaki et al reported that topical application of GALLIC ACID (1% w/v) improved UV-induced hyperpigmentation within four weeks; Yoshimura et al demonstrated that oral administration of GALLIC ACID-rich pomegranate extract (100 mg/kg/day) vs 1000 mg/kg/day) inhibited UV-induced hyperpigmentation in a dose-dependent manner in brown guinea pigs.
In addition, several human clinical trials have also tested the effectiveness of GALLIC ACID in treating hyperpigmentation. A randomized, double-blind, placebo-controlled trial found that oral administration of GALLIC ACID-rich punicic acid tablets (100-200 mg/day) significantly inhibited hyperpigmentation in subjects with mild sunburn from UV exposure. In a randomized, open-label study, Ertam et al compared the efficacy of synthetic 1% GALLIC ACID, naturally derived 1% GALLIC ACID, and 1% arbutin in the treatment of melasma. Both formulations of GALLIC ACID are as effective as the well-known lightening agent arbutin in improving pigment density. - A recent study reported that combination therapy of topical 0.5% GALLIC ACID and 0.1% salicylic acid was as effective as 4% hydroquinone in improving several clinical and instrumental measures of pigmentation.
