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L-Ergothioneine

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Other Name: EGT; L-(+)-ERGOTHIONEINE
INCI Name: ERGOTHIONEINE
Molecular Formula: C9H15N3O2S
Molecular Weight: 229.3
Appearance: White fine powder
Purity: 98%
CAS NO.: 497-30-3
EINECS No.: 207-843-5
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L-Ergothioneine

L-Ergothioneine is a natural compound found in certain fungi, bacteria, and plants. It is also present in various dietary sources like mushrooms, beans, and whole grains. Known for its antioxidant properties, L-Ergothioneine helps protect cells from oxidative stress by neutralizing harmful free radicals. It has potential health benefits in supporting immune function, promoting skin health, and potentially benefiting cognitive and cardiovascular health. L-Ergothioneine is available as a dietary supplement and is used in skincare products for its skin-enhancing properties. Further research is being conducted to understand its optimal dosage, absorption, and specific biological mechanisms.


Functions of L-Ergothioneine In Skincare

- Antioxidant Power: L-Ergothioneine acts as a potent antioxidant in skincare products, protecting the skin from oxidative stress caused by environmental factors like pollution and UV radiation. It helps neutralize free radicals, reducing the risk of premature aging and damage to the skin cells.


- Skin Brightening: L-Ergothioneine has been shown to have skin brightening effects. By reducing oxidative stress and inhibiting melanin production, it can help diminish the appearance of dark spots, hyperpigmentation, and uneven skin tone, promoting a more radiant complexion.


- Anti-Inflammatory Properties: This compound has anti-inflammatory properties, soothing and calming the skin. It can help reduce redness, irritation, and inflammation, making it suitable for sensitive and reactive skin types.


- Collagen Stimulation: L-Ergothioneine has been found to stimulate collagen production in the skin. Collagen is a crucial protein that provides skin with structure and firmness. By promoting collagen synthesis, L-Ergothioneine helps improve skin elasticity and reduce the appearance of fine lines and wrinkles.


- Environmental Protection: L-Ergothioneine serves as a shield against environmental aggressors. It helps to strengthen the skin's natural defense mechanisms, enhancing its ability to cope with external stressors and maintain a healthier, more resilient complexion.


The Potential Health Benefits of L-Ergothioneine

L-Ergothioneine offers numerous potential health benefits. As a powerful antioxidant, it protects cells from oxidative damage caused by free radicals. It may also enhance immune function, promote skin health by reducing signs of aging, support brain function, and potentially improve cardiovascular health. While more research is needed, L-Ergothioneine shows promise in various areas of human health and well-being.


★What are main skincare benefits of L-Ergothioneine?

Ultra-stable free radical scavenger, anti-photoaging & anti-UV damage

Protect mitochondria & cell DNA, reduce oxidative aging

Brighten pigmentation, fade dark spots & red inflammation

Repair photodamage, calm sensitive skin & strengthen barrier

Synergize anti-aging with Pro-Xylane, peptides & retinol


★What is Solubility & formula stability of L-Ergothioneine

Easily soluble in water, insoluble in oil phase.

Extremely stable in wide pH range, not easy to oxidize, heat-resistant & light-stable, friendly to all water-based cosmetic formulas.


★What is the safe addition ratio of L-Ergothioneine in cosmetic end products?

Daily care: 0.1% – 0.3%

High-efficiency anti-aging/anti-spot: 0.3% – 1.0%

No irritation at normal working concentration, safe for sensitive skin


★Can L-Ergothioneine be used with sunscreen/UV ingredients?

Yes, perfectly compatible.

EGT repairs UV-induced oxidative damage & photo-sagging, greatly enhances anti-photoaging effect together with sunscreens. No fixed matching ratio required.


★Can L-Ergothioneine pair with Pro-Xylane, Ectoin, HA?

EGT + Pro-Xylane: Anti-oxidation + dermal anti-sagging, top anti-aging combination

EGT + Ectoin: Double barrier repair, anti-stress & anti-redness

EGT + HA: Deep hydration + long-term anti-oxidationZ


★L-Ergothioneine Day or night use?

Suitable for both morning & night, non-photosensitive at all.

Daytime: Anti-UV oxidation; Nighttime: Repair cellular aging damage.


★Is L-Ergothioneine safe & non-irritating?

Very mild, zero phototoxicity, low sensitization risk.

Approved safe by global cosmetic regulations, suitable for fragile & post-procedure skin.


★How to distinguish authentic L-Ergothioneine?

Check HPLC purity report (≥99% L-type active)

Verify natural fermentation source & chiral structure certificate

Avoid low-cost racemic mixtures with weak efficacy


★Is L-Ergothioneine allowed to be added to cosmetics in China, the EU, the US, South Korea, and Japan?

Yes, L-Ergothioneine (EGT) is legally allowed in cosmetics across China, EU, USA, South Korea and Japan.