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Nonapeptide-1

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Other Name: Melitane; Melanostatine-5
Molecular Formula: C61H87N15O9S
Molecular Weight: 1206.5
Appearance: White powder
Purity: >98%
CAS NO.: 158563-45-2
Package: 10MG/bottle; 1G/bottle; 5G/bottle
Availability:

buy Nonapeptide 1 supplier-zhenyibio


Nonapeptide-1 (also known as Melanostatine-5) is a proprietary peptide originally developed for its antibacterial activity.However, animal studies have shown that melitane can inhibit the synthesis of melanin,which makes it important in the treatment of certain skins. condition.Animal models show that melitane gel can reduce the synthesis of melanin and reduce skin pigmentation in a large extent.Nonapeptide 1 skincare products uased as whitening agent can play a role in the early stage of skin darkening mechanism.Nonapeptide-1 can prevent further activation of tyrosinase, thereby preventing the synthesis of melanin,so as to better control skin tone and brown spots.Melitane for grey hair treatment in cosmetics application.


Melitane-zhenyibio

Nonapeptide-1-zhenyibio

★What is Nonapeptide-1 and how does it work?

Nonapeptide-1 is a synthetic peptide of nine amino acids. It acts as an α-MSH antagonist, binding to MC1 receptors on melanocytes to block melanin production signals before they start.


★How is it different from other whitening ingredients like Vitamin C or Kojic Acid?

Vitamin C and Kojic Acid act downstream on tyrosinase. Nonapeptide-1 works upstream by blocking the hormonal signal (α-MSH) that activates tyrosinase. This prevents pigmentation at the source without irritation.


★Is this peptide listed in China's cosmetic ingredient catalog?

Yes. Nonapeptide-1 is officially listed in China's IECIC (2021 Edition) under sequence number 03642 as a permitted cosmetic ingredient with skin conditioning and hair conditioning functions.


★What is the approved safe usage concentration in China?

China NMPA data shows maximum historical usage: 2% for leave-on products (full body) and 2% for eye area (leave-on) . These concentrations are considered safe for cosmetic use.


★What is the recommended dosage for formulations?

Recommended usage is 5 to 25 ppm (0.0005% – 0.0025%) of active peptide powder. For best results, add during the cooling phase below 40°C at pH 5.0-7.0.


★What is the mechanism behind its skin brightening effect?

It competitively binds to MC1 receptors on melanocytes, preventing α-MSH from activating the melanin synthesis cascade. This downregulates tyrosinase, TRP-1, and MITF gene expression.