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Palmitoyl Tripeptide-5

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Other Name: syn coll peptide; SYN-COL
Molecular Formula: C37H67F6N5O9
Molecular Weight: 839.95
Appearance: White powder
Purity: >98%
CAS NO.: 623172-56-5
Package: 10MG/bottle; 1G/bottle; 5G/bottle
Availability:

buy palmitoyl tripeptide 5 serum powder-zhenyibio


Palmitoyl Tripeptide-5 belongs to the signaling peptide class and is the most widely used cosmetic small molecule peptide. Its cosmetic efficacy is comparable to that of injecting collagen.

Research has shown that such peptides promote the synthesis of collagen (types I, II, and IV) and the generation of extracellular matrix proteins by increasing stromal cell activity, strengthening connective tissue, promoting cell activity, and making the skin appear younger and more elastic. Many famous foreign cosmetics brands (such as Est é e Lauder, Chanel, Avon, etc.) use palmitoyl tripeptide-5 as a nutritional anti wrinkle ingredient because it has the ability to promote the synthesis of collagen and elastin in the dermis, making it an ideal raw material for accelerating collagen production and repairing wrinkles. Adding it to cosmetics can help the skin replenish collagen, enhance facial elasticity, and significantly reduce facial wrinkles. At the same time, it also has the characteristics of enhancing cell activity, increasing skin moisture content, enhancing skin gloss, and improving skin tone. In addition, it also has the effect of moisturizing the lips.



Palmitoyl Tripeptide-5-zhenyibio

★What is Palmitoyl Tripeptide-5 and what makes it unique?

Palmitoyl Tripeptide-5 (CAS: 623172-56-5, Pal-KVK) is a lipopeptide that mimics TGF-β activity. Unlike general collagen stimulators, it activates the TGF-β/Smad pathway to specifically regenerate Type I and III collagen, addressing the root cause of skin elasticity loss.


★What is the collagen regeneration mechanism?

It binds to TGF-β receptors on dermal fibroblasts, activating Smad signaling to upregulate Type I (80% of dermal collagen) and Type III (youthful elasticity) collagen genes. The palmitoyl modification achieves 78% dermal penetration, 3x higher than non-modified peptides.


★What is the recommended dosage?

Standard usage rate is 1% to 5% in finished formulations. For anti-wrinkle serums and firming creams, 2-3% is typical. For daily moisturizers and eye treatments, 1-2% provides effective results. Purity is ≥99% as lyophilized powder.


★What types of products can include Palmitoyl Tripeptide-5?

Palmitoyl Tripeptide-5 can be incorporated into a wide range of cosmetic formulations, including anti-aging serums, wrinkle repair creams, firming lotions, and eye care products. Its versatility makes it suitable for both lightweight and rich formulations targeting mature or aging skin.


★Is Palmitoyl Tripeptide-5 more effective than topical collagen?

Palmitoyl Tripeptide-5 is generally considered more effective than topical collagen because it stimulates the skin to produce its own collagen rather than simply providing surface hydration. This leads to deeper and longer-lasting improvements in skin structure and firmness.


★What is the safety profile?

Palmitoyl Tripeptide-5 has an excellent safety profile as a synthetic biomimetic peptide. It is not on restricted substance lists and shows anti-inflammatory properties. No significant irritation or allergic reactions have been reported at recommended usage levels.