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What is ceramide liposomeand its main function?

Views: 9     Author: Site Editor     Publish Time: 2022-03-07      Origin: Site

The characteristics of liposomal cerasome

The permeation barrier of the stratum corneum is mostly composed of saturated lipids such as Ceramide Liposomeands, cholesterol, and free fatty acids. It is an effective barrier to substance exchange and prevents skin dryness. Cerasomes are a type of liposome whose The membrane is composed of the most important stratum corneum lipids. As a source of skin-like membranes, Ceramide Liposomeand liposomes accelerate the regeneration of damaged barrier layers, reduce skin irritation, and it also provides the application of stratum corneum lipids Simple and effective way to use in cosmetics.

The barrier function of the skin mainly depends on the stratum corneum of the epidermis. The stratum corneum of the epidermis is composed of protein-rich keratinocytes and intercellular lipids, called human skin physiological lipids. Its lipid chemical composition is 50% of Ceramide Liposomeands. 20% of cholesterol and cholesterol esters and 30% of free fatty acids play a vital role in maintaining the stability of the internal environment and preventing physical, chemical and biological damages from the external environment. Studies have shown that the lipids between the stratum corneum cells form a bilayer lipid structure, which is filled between the keratinocytes, which can effectively prevent the loss of water, nutrients and electrolytes in the body, and has a deep moisturizing effect.Ceramide liposomal - ZHENYIBIO

The arrangement of lipids plays an important role in the formation of the stratum corneum barrier. Abnormal lipid structure can affect the barrier function of the epidermis. Ceramide Liposomeand is the main component of lipid, and changes in its quality and quantity can cause changes in lipid structure. When age increases or the skin is damaged, the secretion of Ceramide Liposomeands will decrease, resulting in the stratum corneum unable to retain moisture and nutrients, resulting in dry and rough skin. By externally wiping and supplementing Ceramide Liposomeand, it can increase the adhesion of keratinocytes, reduce the loss of water, and achieve the effect of moisturizing. Studies have shown that the moisturizing effect of a single Ceramide Liposomeand topical on the skin is not ideal. This is because the melting point of Ceramide Liposomeand is relatively high, and its own skin penetration is generally average. When a Ceramide Liposomeand preparation is used alone, it is difficult for the Ceramide Liposomeand in the preparation to be absorbed through the skin.

When physiological lipids are applied externally, they need to enter under the stratum corneum, enter the Golgi apparatus in living cells and then be excreted to build a lipid barrier, so these components usually need to pass through the stratum corneum of the skin. The stratum corneum cells are 10-20 layers of dead cells, and the intercellular space is about 50 nm. Due to the general permeability of Ceramide Liposomeand, it is difficult to penetrate the stratum corneum of the skin and enter the activated stratum corneum.

In addition, Ceramide Liposomeand has a high melting point, poor water solubility, and will interfere with the emulsion interface film, which is easy to precipitate and crystallize from the formula, which affects the stability of the formula, so it is difficult to use high content in the formula, especially in transparent water products. The formula components are relatively simple, and it is difficult to prepare a transparent and stable Ceramide Liposomeand aqueous product.

Traditional liposome preparation methods usually include reverse evaporation method, thin film dispersion method, ultrasonic dispersion method, injection method, double emulsion method, freeze drying method, melting method, freeze-thaw method, spray drying method and so on. However, the preparation technology of these liposomes has many disadvantages, such as complicated operation steps, large deviation of repetition effect, more organic solvent utilization, and difficulty in mass production. And the liposomes prepared by these methods generally have a particle size greater than 50 nm. It is verified by the light transmittance experiment that to prepare a completely transparent aqueous product, the particle size of the liposome is usually below 50 nm.

This product is made from natural skin lipids (Ceramide Liposomeand lipids) and a small amount of cholesterol using modern biotechnology to make liposomes. Skin lipids (Ceramide Liposomeand lipids) are the main components in the stratum corneum of human skin, which have good affinity and moisturizing properties for the skin, can strengthen the stratum corneum of the epidermis, help the epidermis to recover, and promote the biochemical protection of the skin. , can reduce or avoid the rough phosphorous flakes of the skin and the peeling of the epidermis caused by sunlight, so that the skin can be kept smooth and strong, and the lipids of the skin can penetrate the skin more easily after forming liposomes, so the lipids of Ceramide Liposomeands Body Shape can significantly enhance skin care when added to cosmetics.Nanoactive Ceramide - ZHENYIBIO

Liposomes are closed vesicles with artificial lipid bilayer membranes. Such vesicles are similar to micelles formed by surfactants, but micelles are composed of surfactant monolayers whereas liposomes are composed of lipid bilayers. Its hydrophilic and lipophilic properties constitute a barrier to isolate the external environment and the internal environment of the liposome. It is basically impermeable to most water-soluble and fat-soluble substances, so the water-soluble or fat-soluble active ingredients can be are encapsulated within the aqueous or lipid bilayer of liposomes, respectively.

Specification of ceramide liposomal:

1. Appearance: milky white homogeneous emulsion (liposomes are round particles in microscope images).

2. PH value: 5.5~7.0

3. Active ingredients: Ceramide Liposomeand content: 3.0%. Skin lipids are mainly Ceramide Liposomeand substances, and their infrared spectrum is the same as that of Ceramide Liposomeands.

4. Turbidity: After the liposome stock solution is diluted 6 times, the turbidity is ≥0.4.

5. Liposome particle size: 0.5~1.0 micron liposomes account for more than 90%.

6. Stability: No delamination after being kept at 40°C for 12 hours.

7. Hygiene standard:

Skin irritation test: This product has no skin irritation and meets the safety requirements of cosmetics.

Miscellaneous bacteria: <50/g. Enterobacter, Staphylococcus aureus, and Pseudomonas aeruginosa were not detected.

Heavy metals: mercury <5mg/kg, arsenic <10mg/kg, lead <10mg/kg.

Application of nanoactive ceramide:

Recommended dosage is 1% to 5%

The material is stirred and cooled to 50°C, slowly added, then stirred and mixed evenly, and used in creams, lotions, facial masks, lotions and other products.

Features & efficacy of liposomal cerasome III:

It has the functions of efficient moisturizing, anti-wrinkle and anti-aging, enhancing skin barrier function, anti-allergy, softening hair and increasing hair elasticity.

The liposome bilayer structure is more skin-friendly and improves the efficacy of moisturizing and repairing the skin barrier.

Natural Equivalent & Optically Active.