Polyquaternium-73 introduction to effects and application

Why does people have acne?

Acne is caused by three factors:

1. Endocrine factors: 

Male hormones→hyperfunction of sebaceous glands→excessive sebum secretion→sebum retention in hair follicles→propionic acid bacteria proliferation, attention should be paid to spicy food, greasy food, menstruation, mental stress regulation;

2. Keratinization factors: 

Hyperkeratinization → blockage of pores → formation of pimples and sebum retention in hair follicles → proliferation of propionic acid bacteria, that is, the disorder of keratin shedding leads to blockage of hair follicle pores. There is a problem with the stratum corneum shedding, and the oil is mixed with the keratinocytes that have not fallen off, causing the pores of the follicles to be blocked and the accumulation of oil;

3. Bacterial factors: 

Propionibacterium proliferation leads to deterioration, that is, there are more and more oil bacteria in the pores of the hair follicles, and the cells in the body must attack these bacteria, resulting in a very serious inflammatory response.

What is Polyquaternium-73?

Polyquaternium-73 (INCI:QUATERNIUM-73), also known as Pi Aoning, has a strong bactericidal effect, can effectively inhibit the effect of Propionibacterium acnes, can quickly remove acne, and also has the ability to inhibit the formation of melanin and antiseptic. High safety, low dosage also has good effect. Piao Ning is a yellow odorless crystalline powder; it has antibacterial activity against acne and acne; it can be used as a preservative, and has strong killing ability to bacteria, staphylococcus, Escherichia coli, etc., and its antiseptic performance is better than that of parabens. High safety, good thermal and light stability, stable in the range of pH 5.5 to 8.0. In addition, Pionin has an inhibitory effect on the production of melanin. When the dosage is 0.1ppm, it completely inhibits the formation of melanin, which is better than kojic acid. Low dosage and high cost performance.

●Acne care 

●Anti-bacterial 

●Anti-dandruff 

●Deodorant 

●Anti-melanin

What is the effect of pionin quaternium-73?

◆ Strong antibacterial activity: destroys bacterial cell membranes, promotes intercellular degeneration of bacteria, and has strong killing ability against Staphylococcus, Escherichia coli, etc.;

◆ Whitening and freckle removal: Strongly inhibits the formation of melanin, 0.00001% Polyquaternium-73 can inhibit the formation of 83% of melanin;

◆ Anti-acne care: Inhibit Propionibacterium acnes, which can effectively improve acne symptoms;

◆ Anticorrosion.

Polyquaternium-73 application 

Polyquaternium-73 is mainly used in cosmetics for antibacterial, whitening, acne removal, and freckle removal. Acne Gel, etc. Polyquaternium-73 is similar to cyanine dyes. Polyquaternium-73 is also very effective at very low doses, because a single Polyquaternium-73 molecule also has antibacterial activity. Polyquaternium-73 has a very significant effect on P. acnes. It is commonly used as an anti-acne ingredient in Japanese over-the-counter medicines. Clinical studies have shown that rashes can be reduced by 50% after two weeks of use. The bactericidal ability of Polyquaternium-73 makes it useful as a preservative. In vitro data suggest that quat-73 is more effective than methylparaben in various antibacterial and antifungal properties. So just add a small amount of parabens to formulas that contain preservatives, as the Polyquaternium-73 in it is enough for an antibacterial effect. Polyquaternium-73 can be used in cleaning products (face wash, shampoo); acne products, oily skin care products; whitening products; as a synergist for preservatives.

Scars/pimples within 6 months:

We divide the repair of acne pits into four parts (medical beauty is recommended for large areas, and ointment may only play an auxiliary role in preventing aggravation):

1. Infiltrate the dermis to improve the scar environment

2. Balance Collagen

3. Lighten pigmentation

4. Anti-inflammatory and antibacterial

1. Infiltrate the dermis to improve the scar environment (polysulfonic acid mucopolysaccharide) 

Because the wound itself is formed (hyperplasia or atrophy) because it hurts our dermis/or deeper subcutaneous tissue, etc. If it is a wound that hurts the epidermis, the skin will automatically repair. So we need to use "polysulfonic acid mucopolysaccharide" to help us penetrate into the dermis to soften and improve scars.

The role of polysulfonic acid mucopolysaccharide: its role is similar to that of heparin (but its molecule is smaller than heparin, so it can penetrate into the dermis) with its own water-absorbing and moisturizing properties, which can give the skin a comfortable environment to avoid excessive fibroblasts Tension and vigorously replenish collagen. (I saw a friend recommending a gel about heparin. This molecular weight is too fat to penetrate into the dermis)

2. Balance Collagen (Onion Steal)

As mentioned above, hyperplasia and atrophy are caused by too much and too little collagen, otherwise it is just an imprint. So what do we need to do? Yes, it is to balance collagen. What Onion Extract Does: Onion bulb extract contains ingredients such as allicin, caffeic acid, and sinapic acid, which control fibroblasts, promote wound healing, and balance collagen.

3. Lighten Pigmentation (Niacinamide)

Because the scar is a piece of cloth randomly patched by fibroblasts, it is not only unsightly, but it does not have many functions that normal skin should have, such as resisting ultraviolet radiation. Then we all know that a UV damage will be exposed to the sun. Black our skin ah ah ah! The grandma who just passed her 100th birthday next door knows it~ So to prevent and reduce the deposition of pigment, you must use the well-known whitening ingredient "niacinamide"↓

The role of niacinamide: whitening, whitening, white...

4. Anti-inflammatory and antibacterial (Polyquaternium-73)

The role of Polyquaternium-73: Polyquaternium-73 has strong antibacterial activity, destroys bacterial and fungal cell membranes, and has an excellent effect on Propionibacterium acnes; it can also inhibit the formation of melanin; it is powerful and highly safe. In addition, it can synergize with onion bulb extract to enhance antibacterial ability.

Note: It can also be applied in the early days of acne and inflammation, which can play a preventive role.

Large areas of severe/more than six months scars/pimples:

The mechanism of action of all medical and aesthetic projects - "first damage, then repair"

①Ice pick acne pit A, TCA skin reconstruction

This type of medical beauty program is suitable for people who have isolated acne pits / ice pick acne pits on healthy skin. Spot the scar with TCA until the scar turns white. It will scab over in 1-2 weeks.

②Car compartment type acne pit B. Laser therapy

Many close friends have said a lot about this type of medical beauty project. It is suitable for shallow scars/deep scars (carriage/rolling type). Ablation lasers remove damaged scar tissue by melting/evaporating/vaporizing. The most commonly used CO2 lasers and erbium lasers, ablate the surface and tighten the underlying collagen fibers. There is also a non-ablative laser that does not remove scar tissue, but it stimulates new collagen formation. Commonly used non-ablative lasers are NdYAG lasers and diode lasers.

Note: Before the laser treatment, the patient must have no acne for at least 1 year, and has not taken isotretinoin for 1 year, and must not have a scar constitution.

For students who want to do laser medical beauty projects, I personally recommend non-ablative ones, which have less side effects and lower risks.

③ Rolling type acne pit C. Microneedling

Using a microneedle roller to injure the forehead needle to puncture the skin requires a 1.5-2mm microneedle to reach the dermis layer, the skin will bleed, and the micro-wound on the dermis layer will initiate a chain reaction of growth factors, which will eventually lead to the regeneration of collagen.

Note: Before the patient undergoes microneedling treatment, anticoagulation therapy, skin infection, collagen injection, other types of tissue filling within 6 months, and scar constitution are contraindicated.