What are the health benefits of piperine?

Pepper is the most basic ingredient in Indian medicine and is used to treat a variety of diseases. Pharmacological studies have proved that many of their traditional efficacy such as painkillers and antipyretic effects, antioxidant effects, antibacterial effects, etc., piperine is an active ingredient for pepper. At present, piperine has been found to have anti -oxidation, immune regulation, and anti -tumor effects.

The pharmacological effects of piperine

1. Anti -tumor effect

There are many reports on the effects of piperine anti-tumor. Studies have found that piperine can inhibit the lung metastases induced by B16F-10 melanoma. This shows that piperine has the effect of anti -tumor metastasis. Studies have found that oral piperine can significantly reduce the lipid peroxidation levels of lung cancer mice induced by benzene and pyroma, and the content of nucleotide and polyamine synthesis. Its inhibitory mechanism is to protect protein damage and inhibit cell proliferation. In terms of melanoma cell model, piperine can effectively inhibit gene expression of ATF-2, NF-Kappab, and inflammatory cytokine.

2. Antioxidant effect

With the system of DPPH-free radicals, the ability of piperine to clear the ability of this kind of free radical in the water-free ethanol medium can be removed. The ability to remove free radicals can indicate its strength and weakness of its antioxidant ability. Studies have proved that piperine has a certain antioxidant activity. Its antioxidant capacity is equivalent to 60.05%of vitamin C, and it exists in an acidic medium.

3. The role of the central nervous system

At present, it has been studied that piperine has the effects of sedation, hypnosis, anticonoring, skeletal muscle relaxation, and antidepressant. The effect of piperine on animal sleep is studied. Extending the sleeping time of mice induced by Wubi Bibi can also significantly increase the deep sleep of the rabbits. Its mechanism may be related to the increase of 5-hydroxyline in the brain. Studies have found that after 4 weeks of piperine intervention, the decline of its cognitive function has been significantly relieved, mainly due to the protective effect of piperinene and the inhibitory effect of neuritis and oxidative damage.

4. Immune regulation effect

Research on immunotoxicology of piperine shows that the use of piperine gastric mice for five consecutive days has no obvious toxic effect, and the liver weight increases normally. When studying the effects of piperine on thymal cells, it was found that piperine can inhibit the production of active oxygen (ROS) and increase the content of glutathione (GSH), and inhibit the changes in apoptosis and thymus -dependent lymphocyte phenotype.

5. Reduce the occurrence of inflammation

piperine can reduce the occurrence of inflammation and pain. Oral piperine at a dose of 50 mg/kg can significantly reduce the occurrence of inflammation. piperine has anti -inflammatory effects. Pepper -pepper -pepper and their percetes can absorb through the skin, so they can act on subcutaneous tissue, nerves and blood vessels. In addition, pharmacological studies have shown that piperine can prevent the role of atherosclerosis, lowering blood lipids, activity of anticonia and anti -ulcer, protecting the liver, and not damage to the function of testicles. And whether in the body or in vitro, the pepper alkali can also slow the intestinal peristalsis. The role of piperine on the neurological and sexual organs reflects its characteristics of anticonor and dilatation blood vessels.

Application of piperine

1. Nutritional reinforcement agent

Existing studies have shown that piperine compounds help promote the absorption of nutrients such as iron and β-carotene. It is also found that black pepper essential oils can promote gastrointestinal exercise, stimulate gastric acid secretion, and help alleviate indigestion, constipation, abdominal distension and other discomfort.

2. Salt substitute

Black pepper is considered one of the best substitutes for salt. Excessive intake of salt in the diet will damage important organs such as the heart and kidneys, increase blood pressure, and increase the risk of cardiovascular and cerebrovascular diseases such as coronary heart disease and brain stroke. Use black pepper to replace salt, which can add flavor to food and avoid disease risks.

3. Reduce blood lipids

Foreign scholars have found that black pepper essential oils can reduce the level of high -lipid serum cholesterol, free fatty acids, phospholipids, and triglyceride, and increase the concentration of high density lipoprotein.

4. Relieve anxiety and help quit smoking

Studies have found that black pepper essential oils may help reduce the desire and anxiety symptoms of smokers for smokers. At the same time, they can also reduce negative emotions after deprivation of smoking. Some scholars have tried to provide cigarette alternative to cigarettes containing black pepper components.