SFE is especially suitable for the extraction and separation of natural substances rich in biological activity. It uses supercritical fluid as the extraction medium, uses the solvation effect of supercritical fluid to dissolve the liquid or solid mixture to be separated, and then reduces the pressure by reducing the pressure or adjusting the temperature.

Piperine, an extract from black pepper, pepper root, and long pepper, gives peppers its spicy flavor. This extract is marketed as a nutritional supplement and has also been found to increase the absorption of various nutrients. While some of the benefits of piperine have not been well established, it may also have immunosuppressive, tumor suppressive, and antidepressant effects.

The effects and functions of piperine include: prevent cancer, regulate digestion, relieve colds and cough, lose weight, beautify people's skin, and benefit people's teeth.

Pharmacological studies have proved that many of their traditional efficacy such as painkillers and antipyretic effects, antioxidant effects, antibacterial effects, etc., piperine is an active ingredient for pepper.