★Is Hydroxyethylpiperazine Ethane Sulfonic Acid listed in China's cosmetic ingredient catalog?
Yes. HEPES is officially listed in China's IECIC (2021 Edition) under sequence number 05290 . It is not a prohibited substance under China's Safety and Technical Standards for Cosmetics.
★What are the approved safe usage concentrations?
China historical maximum: 10% for leave-on products . The highest use concentration recorded is 8.26% for full-body leave-on and 5% for eye area. For rinse-off products, up to 8.26% is safe.
★What is the recommended dosage for cosmetic formulations?
Recommended usage is 0.1% to 8.26% in finished formulations . For maximum efficacy in exfoliating serums and penetration-enhancing formulas, use at higher concentrations within the safe limit.
★What is te solubility and incorporation method?
HEPES is water-soluble . Dissolve in water before adding to the formulation . For best results, incorporate during the water phase at controlled temperatures.
★What are the potential risk substances in HEPES?
Potential risk substances include dioxane and diethylene glycol that may be introduced during manufacturing. Request testing documentation for these impurities from your supplier.
★Does HEPES comply with EU, US FDA, and ASEAN cosmetic regulations?
Fully aligns with EU EC 1223/2009 (no animal testing required, PIF documentation supported), US FDA cosmetic ingredient safety standards, and ASEAN raw material registration rules. We provide full regulatory documents (COA, MSDS, safety assessment) for global customs clearance and formula filing.
HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID has a certain effect of softening cutin and assisting in whitening; in cosmetics, it is a hydrogen ion buffer, which can control a constant pH range for a long time. Hydroxyethylpiperazine ethane sulfonic acid is a very effective biological buffer, which can reform the stratum corneum and promote the metabolism of skin keratinocytes. It is an important mild exfoliating ingredient.
